Human urokinase contains GalNAcβ(1-4)[Fucα(1-3)]GlcNAcα(1-2) as a novel terminal element in N-linked carbohydrate chains

Vliegenthart, J.F.G.; Bergwerff, A.A.; Thomas-Oates, J.E.; Oostrum, J. van; Kamerling, J.P.

Human urokinase contains GalNAcβ(1-4)[Fucα(1-3)]GlcNAcα(1-2) as a novel terminal element in N-linked carbohydrate chains

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Human urokinase contains GalNAcβ(1-4)[Fucα(1-3)]GlcNAcα(1-2) as a novel terminal element in N-linked carbohydrate chains

Vliegenthart, J.F.G.; Bergwerff, A.A.; Thomas-Oates, J.E.; Oostrum, J. van; Kamerling, J.P.

(1992) FEBS Letters, volume 314, issue 3, pp. 389 - 394

(Article)

Abstract

Structural analysis of enzymically released N-linked carbohydrate chains of human urokinase (urinary-type plasminogen activator) by 1H NMR spectroscopy and FAB-MS demonstrated that the N-linked oligosaccharides on the only N-glycosylation site contain diantennary structures with the novel Ga1NAc beta(1-4)[Fuc alpha(1-3)]G1cNAc beta(1-2) element in the upper or the lower branch

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ISSN: 0014-5793

Publisher: Elsevier Science

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