In vitro human cell-based models: What can they do and what are their limitations?

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In vitro human cell-based models: What can they do and what are their limitations?
 
Lutolf, Matthias P.; Radisic, Milica; Beekman, Jeffrey; Huh, Dan Dongeun; Huch, Meritxell; Turco, Margherita Yayoi; Birgani, Zeinab Niloofar Tahmasebi; Gao, Dong; Yao, Rui; Lin, Hang; Takebe, Takanori
(2024) Trends in biotechnology, volume 187, issue 12, pp. 4439 - 4443
(Comment)
Abstract
It is said that all models are wrong, but some are useful. In vitro human cell-based models are a prime example of this maxim. We asked researchers: when is your model system useful? How can it be made more useful? What are its limitations?
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Keywords: Biotechnology, Bioengineering
DOI: https://doi.org/10.1016/j.tibtech.2024.08.015
ISSN: 0167-7799
Publisher: Elsevier Limited
(Peer reviewed)