Effectiveness of energy conservation management on fatigue and participation in multiple sclerosis: A randomized controlled trial
Blikman, Lyan J.M.; van Meeteren, Jetty; Twisk, Jos W.R.; de Laat, Fred A.J.; de Groot, Vincent; Beckerman, Heleen; Stam, Henk J.; Bussmann, Johannes B.J.; Malekzadeh, A.; Van Den Akker, L. E.; Looijmans, M.; Sanches, S. A.; Dekker, J.; Collette, E. H.; Van Oosten, B. W.; Teunissen, C. E.; Blankenstein, M. A.; Eijssen, I. C.J.M.; Rietberg, M.; Heine, M.; Verschuren, O.; Kwakkel, G.; Visser-Meily, J. M.A.; Van De Port, I. G.L.; Lindeman, E.; Hintzen, R. Q.; Hacking, H. G.A.; Hoogervorst, E. L.; Frequin, S. T.F.M.; Knoop, H.; De Jong, B. A.; Bleijenberg, G.; Verhulsdonck, M. C.; van Munster, E. Th L.; Oosterwijk, C. J.; Aarts, G. J.; TREFAMS-ACE Study Group
(2017) Multiple Sclerosis Journal, volume 23, issue 11, pp. 1527 - 1541
(Article)
Abstract
Background: Fatigue is a frequently reported and disabling symptom in multiple sclerosis (MS). Objective: To investigate the effectiveness of an individual energy conservation management (ECM) intervention on fatigue and participation in persons with primary MS-related fatigue. Methods: A total of 86 severely fatigued and ambulatory adults with a definite diagnosis
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of MS were randomized in a single-blind, two-parallel-arm randomized clinical trial to the ECM group or the information- only control group in outpatient rehabilitation departments. Blinded assessments were carried out at baseline and at 8, 16, 26 and 52 weeks after randomization. Primary outcomes were fatigue (fatigue subscale of Checklist Individual Strength – CIS20r) and participation (Impact on Participation and Autonomy scale – IPA). Results: Modified intention-to-treat analysis was based on 76 randomized patients (ECM, n = 36; MS nurse, n=40). No significant ECM effects were found for fatigue (overall difference CIS20r between the groups = −0.81; 95% confidence interval (CI), −3.71 to 2.11) or for four out of five IPA domains. An overall unfavourable effect was found in the ECM group for the IPA domain social relations (difference between the groups = 0.19; 95% CI, 0.03 to 0.35). Conclusion: The individual ECM format used in this study did not reduce MS-related fatigue and restrictions in participation more than an information-only control condition.
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Keywords: Energy conservation, Fatigue, Fatigue management, Multiple sclerosis, Participation, Randomized controlled trial, Rehabilitation medicine, Neurology, Clinical Neurology
ISSN: 1352-4585
Publisher: SAGE Publications Ltd
Note: Publisher Copyright: © 2017, © The Author(s), 2017.
(Peer reviewed)