Epigenetic and Metabolomic Biomarkers for Biological Age: A Comparative Analysis of Mortality and Frailty Risk
Kuiper, Lieke M; Polinder-Bos, Harmke A; Bizzarri, Daniele; Vojinovic, Dina; Vallerga, Costanza L; Beekman, Marian; Dollé, E T; Ghanbari, Mohsen; Voortman, Trudy; Reinders, Marcel J T; Verschuren, W M Monique; Slagboom, P Eline; van den Akker, Erik B; van Meurs, Joyce B J
(2023) Journals of Gerontology Series A-Biological Sciences and Medical Sciences, volume 78, issue 10, pp. 1753 - 1762
(Article)
Abstract
Biological age captures a person's age-related risk of unfavorable outcomes using biophysiological information. Multivariate biological age measures include frailty scores and molecular biomarkers. These measures are often studied in isolation, but here we present a large-scale study comparing them. In 2 prospective cohorts (n = 3 222), we compared epigenetic
... read more
(DNAm Horvath, DNAm Hannum, DNAm Lin, DNAm epiTOC, DNAm PhenoAge, DNAm DunedinPoAm, DNAm GrimAge, and DNAm Zhang) and metabolomic-based (MetaboAge and MetaboHealth) biomarkers in reflection of biological age, as represented by 5 frailty measures and overall mortality. Biomarkers trained on outcomes with biophysiological and/or mortality information outperformed age-trained biomarkers in frailty reflection and mortality prediction. DNAm GrimAge and MetaboHealth, trained on mortality, showed the strongest association with these outcomes. The associations of DNAm GrimAge and MetaboHealth with frailty and mortality were independent of each other and of the frailty score mimicking clinical geriatric assessment. Epigenetic, metabolomic, and clinical biological age markers seem to capture different aspects of aging. These findings suggest that mortality-trained molecular markers may provide novel phenotype reflecting biological age and strengthen current clinical geriatric health and well-being assessment.
show less
Download/Full Text
Keywords: Aged, Aging/genetics, Biomarkers, DNA Methylation, Epigenesis, Genetic, Frailty/genetics, Humans, Prospective Studies, Journal Article, Research Support, Non-U.S. Gov't
ISSN: 1079-5006
Publisher: Oxford University Press
Note: Publisher Copyright: © The Author(s) 2023. Published by Oxford University Press on behalf of The Gerontological Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https:// creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited.
(Peer reviewed)