Correction: Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene–drug interaction between UGT1A1 and irinotecan (European Journal of Human Genetics, (2023), 31, 9, (982-987), 10.1038/s41431-022-01243-2)

Abstract

Correction to: European Journal of Human Genetics, published online 28 November 2022 Supplementary Table 3 contained two incorrectly predicted phenotypes based on the described genetic variant combinations (rs number variants). Supplementary Table 3 has been simplified and updated accordingly. (Table presented.) Genotype to predicted phenotype translation to be programmed into laboratory information system. Genotype rs number variants Nucleotide at position Predicted phenotype UGT1A1: WILDTYPE/WILDTYPE UGT1A1_rs35350960 UGT1A1_rs4148323 UGT1A1_rs8175347 C:C G:G -:- *1/*1 (TA6/TA6) UGT1A1:*28/*37/*28/*37 UGT1A1_rs35350960 UGT1A1_rs4148323 UGT1A1_rs8175347 C:C G:G TA:TA *28/*28 (TA7/TA7) UGT1A1:WILDTYPE/*28/*37 UGT1A1_rs35350960 UGT1A1_rs4148323 UGT1A1_rs8175347 C:C G:G -:TA *1/*28 (TA6/TA7) UGT1A1:*27/*27 UGT1A1_rs35350960 UGT1A1_rs4148323 UGT1A1_rs8175347 A:A G:G -:- PM otherwise UGT1A1:WILDTYPE/*27 UGT1A1_rs35350960 UGT1A1_rs4148323 UGT1A1_rs8175347 C:A G:G -:- IM otherwise UGT1A1:WILDTYPE/*27_WILDTYPE/*28/*37 UGT1A1_rs35350960 UGT1A1_rs4148323 UGT1A1_rs8175347 C:A G:G -:TA PM otherwise UGT1A1:*6/*6 UGT1A1_rs35350960 UGT1A1_rs4148323 UGT1A1_rs8175347 C:C A:A -:- PM otherwise UGT1A1:WILDTYPE/*6 UGT1A1_rs35350960 UGT1A1_rs4148323 UGT1A1_rs8175347 C:C G:A -:- IM otherwise UGT1A1:WILDTYPE/*6_WILDTYPE/*28/*37 UGT1A1_rs35350960 UGT1A1_rs4148323 UGT1A1_rs8175347 C:C G:A -:TA PM otherwise UGT1A1:WILDTYPE/*27_WILDTYPE/*6 UGT1A1_rs35350960 UGT1A1_rs4148323 UGT1A1_rs8175347 C:A G:A -:- PM otherwise This table includes UGT1A1 alleles with a minor allele frequency ≥ 1% in either the White, African or Asian population. According to the allele definition table of PharmGKB, there is no allele including two of the polymorphisms (, accessed on 16 December 2022). This suggests that alleles including two or more of these polymorphisms are either very rare or non-existent. For this reason, genotypes with 3 or 4 polymorphisms were not included in the translation table. In addition, in compound heterozygotes, both polymorphisms were considered to be on different alleles.