Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials: Initial QUARTET experience

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Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials: Initial QUARTET experience
 
Turcas, Andrada; Kelly, Sarah M.; Bernier-Chastagner, Valérie; Bolle, Stephanie; Cameron, Alison; Corning, Coreen; Clementel, Enrico; Dieckmann, Karin; Davila Fajardo, Raquel; Gaze, Mark N.; Laprie, Anne; Magelssen, Henriette; Meroni, Silvia; Pignoli, Emanuele; Safwat, Akmal; Scarzello, Giovanni; Talbot, James; Timmermann, Beate; Boterberg, Tom; Mandeville, Henry C.
(2023) Radiotherapy and Oncology, volume 187, pp. 1 - 5
(Article)
Abstract
Irradiation of the vertebrae in prepubertal patients, if non-homogenous, can result in future growth deformities including kyphoscoliosis. Vertebral delineation and dosimetry were assessed for 101 paediatric cases reviewed within QUARTET-affiliated trials. Despite the availability of published consensus guidelines, a high variability in vertebral delineation was observed, with impact on dosimetry.
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Keywords: Clinical trial, Pediatrics, Quality assurance, Radiotherapy, Vertebrae, Hematology, Oncology, Radiology Nuclear Medicine and imaging
DOI: https://doi.org/10.1016/j.radonc.2023.109810
ISSN: 0167-8140
Publisher: Elsevier Ireland Ltd
Note: Publisher Copyright: © 2023 The Authors
(Peer reviewed)