A genomic appraisal of invasive Salmonella Typhimurium and associated antibiotic resistance in sub-Saharan Africa
Van Puyvelde, Sandra; de Block, Tessa; Sridhar, Sushmita; Bawn, Matt; Kingsley, Robert A.; Ingelbeen, Brecht; Beale, Mathew A.; Barbé, Barbara; Jeon, Hyon Jin; Mbuyi-Kalonji, Lisette; Phoba, Marie France; Falay, Dadi; Martiny, Delphine; Vandenberg, Olivier; Affolabi, Dissou; Rutanga, Jean Pierre; Ceyssens, Pieter Jan; Mattheus, Wesley; Cuypers, Wim L.; van der Sande, Marianne A.B.; Park, Se Eun; Kariuki, Simon; Otieno, Kephas; Lusingu, John P.A.; Mbwana, Joyce R.; Adjei, Samuel; Sarfo, Anima; Agyei, Seth O.; Asante, Kwaku P.; Otieno, Walter; Otieno, Lucas; Tahita, Marc C.; Lompo, Palpouguini; Hoffman, Irving F.; Mvalo, Tisungane; Msefula, Chisomo; Hassan-Hanga, Fatimah; Obaro, Stephen; Mackenzie, Grant; Deborggraeve, Stijn; Feasey, Nicholas; Marks, Florian; MacLennan, Calman A.; Thomson, Nicholas R.; Jacobs, Jan; Dougan, Gordon; Kariuki, Samuel; Lunguya, Octavie
(2023) Nature Communications, volume 14, issue 1
(Article)
Abstract
Invasive non-typhoidal Salmonella (iNTS) disease manifesting as bloodstream infection with high mortality is responsible for a huge public health burden in sub-Saharan Africa. Salmonella enterica serovar Typhimurium (S. Typhimurium) is the main cause of iNTS disease in Africa. By analysing whole genome sequence data from 1303 S. Typhimurium isolates originating
... read more
from 19 African countries and isolated between 1979 and 2017, here we show a thorough scaled appraisal of the population structure of iNTS disease caused by S. Typhimurium across many of Africa’s most impacted countries. At least six invasive S. Typhimurium clades have already emerged, with ST313 lineage 2 or ST313-L2 driving the current pandemic. ST313-L2 likely emerged in the Democratic Republic of Congo around 1980 and further spread in the mid 1990s. We observed plasmid-borne as well as chromosomally encoded fluoroquinolone resistance underlying emergences of extensive-drug and pan-drug resistance. Our work provides an overview of the evolution of invasive S. Typhimurium disease, and can be exploited to target control measures.
show less
Download/Full Text
Keywords: General Chemistry, General Biochemistry,Genetics and Molecular Biology, General Physics and Astronomy, Journal Article
ISSN: 2041-1723
Publisher: Nature Publishing Group
Note: Publisher Copyright: © 2023, Springer Nature Limited.
(Peer reviewed)