Seasonal variation of anti-PD-1 outcome in melanoma-Results from a Dutch patient cohort
Borgers, J S W; Burgers, F H; Schina, A; Van Not, O J; van den Eertwegh, A J M; Blank, C U; Aarts, M J B; van den Berkmortel, F W P J; de Groot, J W B; Hospers, G A P; Kapiteijn, E; Piersma, D; van Rijn, R S; Boer, A M Stevense-den; van der Veldt, A A M; Vreugdenhil, G; Boers-Sonderen, M J; Wouters, M W J M; Suijkerbuijk, K P M; van Thienen, J V; Haanen, J B A G
(2024) Pigment Cell and Melanoma Research, volume 37, issue 1, pp. 15 - 20
(Comment)
Abstract
Despite the improved survival rates of patients with advanced stage melanoma since the introduction of ICIs, many patients do not have (long-term) benefit from these treatments. There is evidence that the exposome, an accumulation of host-extrinsic factors including environmental influences, could impact ICI response. Recently, a survival benefit was observed
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in patients with BRAF wild-type melanoma living in Denmark who initiated immunotherapy in summer as compared to winter. As the Netherlands lies in close geographical proximity to Denmark and has comparable seasonal differences, a Dutch validation cohort was established using data from our nationwide melanoma registry. In this study, we did not observe a similar seasonal difference in overall survival and are therefore unable to confirm the Danish findings. Validation of either the Dutch or Danish findings in (combined) patient cohorts from other countries would be necessary to determine whether this host-extrinsic factor influences the response to ICI-treatment.
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Keywords: General Biochemistry,Genetics and Molecular Biology, Dermatology, Oncology, Letter
ISSN: 1755-1471
Publisher: Wiley-Blackwell
Note: Funding Information: No funding was obtained for this manuscript. The Dutch Institute for Clinical Auditing (DICA) foundation received a start‐up grant for the Dutch Melanoma Treatment Registry (DMTR) from The Netherlands Organization for Health Research and Development (ZonMW, project number 836002002). The DMTR is structurally funded by Bristol‐Myers Squibb, Merck Sharpe & Dohme, Novartis, and Roche Pharma. Roche Pharma ended their funding in 2019, and Pierre Fabre started funding the DMTR in 2019. Publisher Copyright: © 2023 The Authors. Pigment Cell & Melanoma Research published by John Wiley & Sons Ltd.
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