Mother-to-infant microbiota transmission and infant microbiota development across multiple body sites
Bogaert, Debby; van Beveren, Gina J.; de Koff, Emma M.; Lusarreta Parga, Paula; Balcazar Lopez, Carlos E.; Koppensteiner, Lilian; Clerc, Melanie; Hasrat, Raiza; Arp, Kayleigh; Chu, Mei Ling J.N.; de Groot, Pieter C.M.; Sanders, Elisabeth A.M.; van Houten, Marlies A.; de Steenhuijsen Piters, Wouter A.A.
(2023) Cell Host and Microbe, volume 31, issue 3, pp. 447 - 460.e6
(Article)
Abstract
Early-life microbiota seeding and subsequent development is crucial to future health. Cesarean-section (CS) birth, as opposed to vaginal delivery, affects early mother-to-infant transmission of microbes. Here, we assess mother-to-infant microbiota seeding and early-life microbiota development across six maternal and four infant niches over the first 30 days of life in
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120 mother-infant pairs. Across all infants, we estimate that on average 58.5% of the infant microbiota composition can be attributed to any of the maternal source communities. All maternal source communities seed multiple infant niches. We identify shared and niche-specific host/environmental factors shaping the infant microbiota. In CS-born infants, we report reduced seeding of infant fecal microbiota by maternal fecal microbes, whereas colonization with breastmilk microbiota is increased when compared with vaginally born infants. Therefore, our data suggest auxiliary routes of mother-to-infant microbial seeding, which may compensate for one another, ensuring that essential microbes/microbial functions are transferred irrespective of disrupted transmission routes.
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Keywords: 16S-rRNA sequencing, Bacteroides, cesarean section, development, early-life, heritability, microbiome, microbiota, mother-infant transmission, seeding, Parasitology, Microbiology, Virology
ISSN: 1931-3128
Publisher: Cell Press
Note: Funding Information: The authors would like to thank all families who participated in this study. We are indebted to Astrid A.T.M. Bosch and all members of the Spaarne Gasthuis Academy research team for their dedication and practical support with participant enrollment and sample collection. This work was supported in part by the Dutch Research Council (NWO)_ through a VIDI-grant ( 91715359 ) and CSO/NRS through a Scottish Senior Clinical Fellowship award ( SCAF/16/03 ). Funding Information: D.B. received funding from OM Pharma and GlaxoSmithKline for studies unrelated to this work. Funding Information: The authors would like to thank all families who participated in this study. We are indebted to Astrid A.T.M. Bosch and all members of the Spaarne Gasthuis Academy research team for their dedication and practical support with participant enrollment and sample collection. This work was supported in part by the Dutch Research Council (NWO)_ through a VIDI-grant(91715359) and CSO/NRS through a Scottish Senior Clinical Fellowship award (SCAF/16/03). Conceptualization, D.B. M.A.v.H. and E.A.M.S.; resources, M.A.v.H. and P.C.M.d.G.; investigation, R.H. K.A. P.L.P. C.E.B.L. L.K. M.C. and M.L.J.N.C.; formal analysis, G.J.v.B. E.M.d.K. and W.A.A.d.S.P.; visualization, W.A.A.d.S.P.; writing – original draft, D.B. and W.A.A.d.S.P.; writing – review & editing, all authors; supervision, M.A.v.H. P.C.M.d.G. D.B. and W.A.A.d.S.P.; funding acquisition, D.B. D.B. received funding from OM Pharma and GlaxoSmithKline for studies unrelated to this work. We support inclusive, diverse, and equitable conduct of research. Publisher Copyright: © 2023 Elsevier Inc.
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