Developmental trajectory of transmission speed in the human brain
van Blooijs, Dorien; van den Boom, Max A; van der Aar, Jaap F; Huiskamp, Geertjan M; Castegnaro, Giulio; Demuru, Matteo; Zweiphenning, Willemiek J E M; van Eijsden, Pieter; Miller, Kai J; Leijten, Frans S S; Hermes, Dora
(2023) Nature Neuroscience, volume 26, issue 4, pp. 537 - 541
(Article)
Abstract
The structure of the human connectome develops from childhood throughout adolescence to middle age, but how these structural changes affect the speed of neuronal signaling is not well described. In 74 subjects, we measured the latency of cortico-cortical evoked responses across association and U-fibers and calculated their corresponding transmission speeds.
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Decreases in conduction delays until at least 30 years show that the speed of neuronal communication develops well into adulthood.
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Keywords: General Neuroscience, Journal Article
ISSN: 1097-6256
Publisher: Nature Research
Note: Funding Information: We thank the SEIN-UMCU RESPect database group (C.J.J. van Asch, L. van de Berg, S. Blok, M.D. Bourez, K.P.J. Braun, J.W. Dankbaar, C.H. Ferrier, T.A. Gebbink, P.H. Gosselaar, M.G.G. Hobbelink, F.W.A. Hoefnagels, N.E.C. van Klink, M.A. van ‘t Klooster, G.A.P. de Kort, M.H.M. Mantione, A. Muhlebner, J.M. Ophorst, R. van Regteren, P.C. van Rijen, S.M.A. van der Salm, E.V. Schaft, M.M.J. van Schooneveld, H. Smeding, D. Sun, A. Velders, M.J.E. van Zandvoort, G.J.M. Zijlmans, E. Zuidhoek and J. Zwemmer) for their contributions and help in collecting the data, and G. Ojeda Valencia for proofreading the manuscript. Research reported in this publication was supported by the National Institute of Mental Health of the National Institutes of Health under Award Number R01MH122258 (D.H. and F.S.S.L.), the content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health, the EpilepsieNL under Award Number NEF17-07 (D.v.B.) and the UMC Utrecht Alexandre Suerman MD/PhD Stipendium 2015 (W.J.E.M.Z.). Funding Information: We thank the SEIN-UMCU RESPect database group (C.J.J. van Asch, L. van de Berg, S. Blok, M.D. Bourez, K.P.J. Braun, J.W. Dankbaar, C.H. Ferrier, T.A. Gebbink, P.H. Gosselaar, M.G.G. Hobbelink, F.W.A. Hoefnagels, N.E.C. van Klink, M.A. van ‘t Klooster, G.A.P. de Kort, M.H.M. Mantione, A. Muhlebner, J.M. Ophorst, R. van Regteren, P.C. van Rijen, S.M.A. van der Salm, E.V. Schaft, M.M.J. van Schooneveld, H. Smeding, D. Sun, A. Velders, M.J.E. van Zandvoort, G.J.M. Zijlmans, E. Zuidhoek and J. Zwemmer) for their contributions and help in collecting the data, and G. Ojeda Valencia for proofreading the manuscript. Research reported in this publication was supported by the National Institute of Mental Health of the National Institutes of Health under Award Number R01MH122258 (D.H. and F.S.S.L.), the content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health, the EpilepsieNL under Award Number NEF17-07 (D.v.B.) and the UMC Utrecht Alexandre Suerman MD/PhD Stipendium 2015 (W.J.E.M.Z.). Publisher Copyright: © 2023, The Author(s).
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