Long-term effects of premenopausal risk-reducing salpingo-oophorectomy on cognition in women with high familial risk of ovarian cancer: A cross-sectional study
Terra, Lara; Lee Meeuw Kjoe, Philippe R.; Agelink van Rentergem, Joost A.; Beekman, Maarten J.; Heemskerk-Gerritsen, Bernadette A.M.; van Beurden, Marc; Roeters van Lennep, Jeanine E.; van Doorn, Helena C.; de Hullu, Joanna A.; Mourits, Marian J.E.; van Dorst, Eleonora B.L.; Mom, Constantijne H.; Slangen, Brigitte F.M.; Gaarenstroom, Katja N.; van der Kolk, Lizet E.; Collée, J. Margriet; Wevers, Marijke R.; Ausems, Margreet G.E.M.; van Engelen, Klaartje; van de Beek, Irma; Berger, Lieke P.V.; van Asperen, Christi J.; Gomez Garcia, Encarna B.; Maas, Angela H.E.M.; Hooning, Maartje J.; van der Wall, Elsken; van Leeuwen, Flora E.; Schagen, Sanne B.
(2023) BJOG: An International Journal of Obstetrics and Gynaecology, volume 130, issue 8, pp. 968 - 977
(Article)
Abstract
Objective: To examine the effect of a premenopausal risk-reducing salpingo-oophorectomy (RRSO) in women at increased risk of ovarian cancer on objective and subjective cognition at least 10 years after RRSO. Design: A cross-sectional study with prospective follow-up, nested in a nationwide cohort. Setting: Multicentre in the Netherlands. Population or Sample:
... read more
641 women (66% BRCA1/2 pathogenic variant carriers) who underwent either a premenopausal RRSO ≤ age 45 (n = 436) or a postmenopausal RRSO ≥ age 54 (n = 205). All participants were older than 55 years at recruitment. Methods: Participants completed an online cognitive test battery and a questionnaire on subjective cognition. We used multivariable regression analyses, adjusting for age, education, breast cancer, hormone replacement therapy, cardiovascular risk factors and depression. Main Outcome Measures: The influence of RRSO on objective and subjective cognition of women with a premenopausal RRSO compared with women with a postmenopausal RRSO. Results: After adjustment, women with a premenopausal RRSO (mean time since RRSO 18.2 years) performed similarly on objective cognitive tests compared with women with a postmenopausal RRSO (mean time since RRSO 11.9 years). However, they more frequently reported problems with reasoning (odds ratio [OR] 1.8, 95% confidence interval [95% CI] 1.1–3.1) and multitasking (OR 1.9, 95% CI 1.1–3.4) than women with a postmenopausal RRSO. This difference between groups disappeared in an analysis restricted to women of comparable ages (60–70 years). Conclusions: Reassuringly, approximately 18 years after RRSO, we found no association between premenopausal RRSO and objective cognition.
show less
Download/Full Text
The full text of this publication is not available.
Keywords: BRCA1/2 pathogenic variant carriers, cognitive functioning, premature menopause, risk-reducing salpingo-oophorectomy, Obstetrics and Gynaecology, Journal Article
ISSN: 1470-0328
Publisher: Wiley-Blackwell
Note: Funding Information: The Dutch Cancer Society (KWF) granted funding for this project, registered under grant 10164. This study was peer‐reviewed by the Dutch Cancer Society and several patient panels before granting funding. The funding body had no role in the design of the study, collection, analysis, and interpretation of data or in writing the article. Publisher Copyright: © 2023 John Wiley & Sons Ltd.
(Peer reviewed)