Prevalence, risk factors, and long-term outcomes of cerebral ischemia in hospitalized COVID-19 patients - study rationale and protocol of the CORONIS study: A multicentre prospective cohort study
van Lith, Theresa J; Sluis, Wouter M; Wijers, Naomi T; Meijer, Frederick Ja; Kamphuis-van Ulzen, Karin; de Bresser, Jeroen; Dankbaar, Jan Willem; van den Heuvel, Frederik Ma; Antoni, M Louisa; Mulders-Manders, Catharina M; de Mast, Quirijn; van de Veerdonk, Frank L; Klok, Frederikus A; Tuladhar, Anil M; Cannegieter, Suzanne C; Wermer, Marieke Jh; van der Worp, H Bart; Huisman, Menno V; de Leeuw, Frank-Erik
(2022) European Stroke Journal, volume 7, issue 2, pp. 180 - 187
(Article)
Abstract
BACKGROUND: COVID-19 is often complicated by thrombo-embolic events including ischemic stroke. The underlying mechanisms of COVID-19-associated ischemic stroke, the incidence and risk factors of silent cerebral ischemia, and the long-term functional outcome in these patients are currently unknown. PATIENTS AND METHODS: CORONavirus and Ischemic Stroke (CORONIS) is a multicentre prospective
... read more
cohort study investigating the prevalence, risk factors and long-term incidence of (silent) cerebral ischemia, and the long-term functional outcome among patients with COVID-19. We aim to include 200 adult patients hospitalized with COVID-19 without symptomatic ischemic stroke to investigate the prevalence of silent cerebral ischemia compared with 60 (matched) controls with MRI. In addition, we will identify potential risk factors and/or causes of cerebral ischemia in COVID-19 patients with (n = 70) or without symptomatic stroke (n = 200) by means of blood sampling, cardiac workup and brain MRI. We will measure functional outcome and cognitive function after 3 and 12 months with standardized questionnaires in all patients with COVID-19. Finally, the long-term incidence of (new) silent cerebral ischemia in patients with COVID-19 will be assessed with follow up MRI (n = 120). SUMMARY: The CORONIS study is designed to add further insight into the prevalence, long-term incidence and risk factors of cerebral ischemia, and the long-term functional outcome in hospitalized adult patients with COVID-19.
show less
Download/Full Text
Keywords: COVID-19, SARS-CoV-2, ischemic stroke, silent cerebral ischemia, Clinical Neurology, Cardiology and Cardiovascular Medicine, Journal Article
ISSN: 2396-9873
Publisher: SAGE Publications Inc.
Note: Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work is supported by The Netherlands Organisation for Health Research and Development (ZonMw) and The Heart Council (grant number 10430012010014). Publisher Copyright: © European Stroke Organisation 2022.
(Peer reviewed)