A diffusion tensor imaging analysis of white matter microstructures in non-operated craniosynostosis patients
de Planque, C A; Florisson, J M G; Tasker, R C; Rijken, B F M; van Veelen, M L C; Mathijssen, I M J; Lequin, M H; Dremmen, M H G
(2022) Neuroradiology, volume 64, issue 12, pp. 2391 - 2398
(Article)
Abstract
Purpose: In 7 to 15-year-old operated syndromic craniosynostosis patients, we have shown the presence of microstructural anomalies in brain white matter by using DTI. To learn more about the cause of these anomalies, the aim of the study is to determine diffusivity values in white matter tracts in non-operated syndromic
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craniosynostosis patients aged 0–2 years compared to healthy controls. Methods: DTI datasets of 51 non-operated patients with syndromic craniosynostosis with a median [IQR] age of 0.40 [0.25] years were compared with 17 control subjects with a median of 1.20 [0.85] years. Major white matter tract pathways were reconstructed with ExploreDTI from MRI brain datasets acquired on a 1.5 T MRI system. Eigenvalues of these tract data were examined, with subsequent assessment of the affected tracts. Having syndromic craniosynostosis (versus control), gender, age, frontal occipital horn ratio (FOHR), and tract volume were treated as independent variables. Results: ʎ 2 and ʎ 3 of the tracts genu of the corpus callosum and the hippocampal segment of the cingulum bundle show a ƞ 2 > 0.14 in the comparison of patients vs controls, which indicates a large effect on radial diffusivity. Subsequent linear regressions on radial diffusivity of these tracts show that age and FOHR are significantly associated interacting factors on radial diffusivity (p < 0.025). Conclusion: Syndromic craniosynostosis shows not to be a significant factor influencing the major white matter tracts. Enlargement of the ventricles show to be a significant factor on radial diffusivity in the tracts corpus callosum genu and the hippocampal segment of the cingulate bundle.
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Keywords: Adolescent, Anisotropy, Case-Control Studies, Child, Corpus Callosum, Craniosynostoses/diagnostic imaging, Diffusion Magnetic Resonance Imaging/methods, Diffusion Tensor Imaging/methods, Humans, White Matter/diagnostic imaging, Craniosynostosis, Tractography, Syndrome, Diffusion tensor imaging, DTI, Clinical Neurology, Cardiology and Cardiovascular Medicine, Radiology Nuclear Medicine and imaging, Journal Article
ISSN: 0028-3940
Publisher: Springer Verlag
Note: Funding Information: Research of C.A.P. was supported by the foundation “Sophia Stichting Wetenschappelijk Onderzoek” (project number: B-16-03a); they had no involvement in any aspect of the study. Publisher Copyright: © 2022, The Author(s).
(Peer reviewed)