Impact of rituximab on treatment outcomes of patients with angioimmunoblastic T-cell lymphoma; a population-based analysis
Meeuwes, Frederik O.; Brink, Mirian; van der Poel, Marjolein W.M.; Kersten, Marie José; Wondergem, Mariëlle; Mutsaers, Pim G.N.J.; Böhmer, Lara; Woei-A-Jin, Sherida; Visser, Otto; Oostvogels, Rimke; Jansen, Patty M.; Diepstra, Arjan; Snijders, Tjeerd J.F.; Plattel, Wouter J.; Huls, Gerwin A.; Vermaat, Joost S.P.; Nijland, Marcel
(2022) European Journal of Cancer, volume 176, pp. 100 - 109
(Article)
Abstract
BACKGROUND: Patients with angioimmunoblastic T-cell lymphoma (AITL) are treated with cyclophosphamide, doxorubicin, vincristine and prednisone with or without etoposide (CHO(E)P). In the majority of cases, Epstein-Barr virus (EBV)-positive B-cells are present in the tumour. There is paucity of research examining the effect of rituximab when added to CHO(E)P. In this
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nationwide, population-based study, we analysed the impact of rituximab on overall response rate (ORR), progression-free survival (PFS) and overall survival (OS) of patients with AITL. METHODS: Patients with AITL diagnosed between 2014 and 2020 treated with ≥one cycle of CHO(E)P with or without rituximab were identified in the Netherlands Cancer Registry. Survival follow-up was up to 1st February 2022. Baseline characteristics, best response during first-line treatment and survival were collected. PFS was defined as the time from diagnosis to relapse or to all-cause-death. OS was defined as the time from diagnosis to all-cause-death. Multivariable analysis for the risk of mortality was performed using Cox regression. FINDINGS: Out of 335 patients, 146 patients (44%) received R-CHO(E)P. Rituximab was more frequently used in patients with a B-cell infiltrate (71% versus 89%, p < 0·01). The proportion of patients who received autologous stem cell transplantation (ASCT) was similar between CHO(E)P and R-CHO(E)P (27% versus 30%, respectively). The ORR and 2-year PFS for patients who received CHO(E)P and R-CHO(E)P were 71% and 78% (p = 0·01), and 40% and 45% (p = 0·12), respectively. The 5-year OS was 47% and 40% (p = 0·99), respectively. In multivariable analysis, IPI-score 3-5, no B-cell infiltrate and no ASCT were independent prognostic factors for risk of mortality, whereas the use of rituximab was not. INTERPRETATION: Although the addition of rituximab to CHO(E)P improved ORR for patients with AITL, the PFS and OS did not improve.
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Keywords: Angioimmunoblastic T-cell lymphoma, Outcome, Peripheral T-cell lymphoma, Rituximab, Treatment, Cyclophosphamide/therapeutic use, Prednisone/therapeutic use, Antibodies, Monoclonal, Murine-Derived/therapeutic use, Lymphoma, Large B-Cell, Diffuse/pathology, Humans, Neoplasm Recurrence, Local, Hematopoietic Stem Cell Transplantation, Transplantation, Autologous, Treatment Outcome, Herpesvirus 4, Human, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Rituximab/therapeutic use, Retrospective Studies, Epstein-Barr Virus Infections, Vincristine/therapeutic use, Doxorubicin/therapeutic use, Lymphoma, T-Cell/drug therapy, Oncology, Cancer Research, Journal Article
ISSN: 0959-8049
Publisher: Elsevier Limited
Note: Funding Information: The authors would like to thank the registrars of the Netherlands Cancer Registry (NCR) for their dedicated data collection. The nationwide population-based NCR is maintained and hosted by the Netherlands Comprehensive Cancer Organisation (IKNL). Publisher Copyright: © 2022 The Author(s)
(Peer reviewed)
