Targeting the high affinity receptor, FcγRI, in autoimmune disease, neuropathy, and cancer

Abstract

ADCC/ADCP: Antibody-dependent cellular cytotoxicity/phagocytosis; AIA: Antigen-induced arthritis; ATG: Anti-thymocyte globulin; bsAbs: Bispecific antibodies; CDC: Complement-dependent cytotoxicity; CIA: Collagen-induced arthritis; CY: Cytoplasmic; DRG: Dorsal root ganglion; EC: Extracellular domain; Fab: Antigen-binding fragment; FcγR: Fc gamma receptor; G-CSF: Granulocyte colony-stimulating factor; IC: Immune complex; INF-y: Interferon gamma; ITAM/ITIM: Immunoreceptor tyrosine-based activation/inhibition motif; ITP: Immune Thrombocytopenic Purpura; IVIg: Intravenous immunoglobulin; LN: Lupus nephritis; mAb: Monoclonal antibody; MCP-1: Monocyte chemoattractant protein 1; NK: Natural killer cell; PMN: Polymorphonuclear; PP1: Protein phosphatase 1; RA: Rheumatoid Arthritis; SLE: Systemic lupus erythematosus; TNF-α: Tumor necrosis factor alpha.