Note: Funding Information: The collaboration between Elif Keles and Karel Allegaert is supported by the European Society of Paediatric Research (ESPR) mentoring program. Pia Wintermark received research grant funding from the FRQS Clinical Research Scholar Career Award Senior and a Canadian Institutes of Health Research (CIHR) Project Grant. Anne Smits is supported by the Clinical Research and Education Council, University Hospitals Leuven. The clinical research of Anne Smits, Pieter Annaert, and Karel Allegaert is supported by the I-PREDICT (FWO senior research project, fundamental research, GOD0520N) grant. Malcolm R Battin is supported by a HRC Clinical Practitioner Fellowship.