White matter hyperintensity shape is associated with cognitive functioning - the SMART-MR study

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White matter hyperintensity shape is associated with cognitive functioning - the SMART-MR study
 
UCC-SMART Study Group
(2022) Neurobiology of Aging, volume 120, pp. 81 - 87
(Article)
Abstract
White matter hyperintensity (WMH) shape has been associated with the severity of the underlying brain pathology, suggesting it is a potential neuroimaging marker of WMH impact on brain function. In 563 patients with vascular disease (58 ± 10 years), we examined the relationship between WMH volume, shape, and cognitive functioning. ... read more
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Keywords: Aging, Cognitive functioning, MRI, Shape analysis, SMART-MR study, White matter hyperintensities, Clinical Neurology, Geriatrics and Gerontology, Ageing, General Neuroscience, Developmental Biology, Journal Article
DOI: https://doi.org/10.1016/j.neurobiolaging.2022.08.009
ISSN: 0197-4580
Publisher: Elsevier Inc.
Note: Funding Information: The research of Jeroen Hendrikse has received funding from the European Research Council under the European Union's Horizon 2020 Programme (H2020) / ERC grant agreement no. 637024 (HEARTOFSTROKE) and H2020 grant agreement No 666881 , SVDs@target. Jeroen Hendrikse is supported by the Netherlands Organization for Scientific Research (NWO ) under grant no. 91712322 . The research of Jeroen de Bresser is supported by Alzheimer Nederland under grant WE.03-2019-08. We thank all the members of the Utrecht Cardiovascular Cohort-Second Manifestations of ARTerial disease-Studygroup (UCC-SMART Study Group): F.W. Asselbergs and H.M. Nathoe, Department of Cardiology; G.J. de Borst, Department of Vascular Surgery; M.L. Bots and M.I. Geerlings, Julius Center for health Sciences and Primary Care; M.H. Emmelot, Department of Geriatrics; P.A. de Jong and T. Leiner, Department of Radiology; A.T. Lely, Department of Obstetrics & Gynecology; N.P. van der Kaaij, Department of Cardiothoracic Surgery; L.J. Kappelle and Y.M. Ruigrok, Department of Neurology; M.C. Verhaar, Department of Nephrology, F.L.J. Visseren (chair) and J. Westerink, Department of Vascular Medicine, University Medical Center Utrecht and Utrecht University. Funding Information: The research of Jeroen Hendrikse has received funding from the European Research Council under the European Union's Horizon 2020 Programme (H2020) / ERC grant agreement no. 637024 (HEARTOFSTROKE) and H2020 grant agreement No 666881, SVDs@target. Jeroen Hendrikse is supported by the Netherlands Organization for Scientific Research (NWO) under grant no. 91712322. The research of Jeroen de Bresser is supported by Alzheimer Nederland under grant WE.03-2019-08. We thank all the members of the Utrecht Cardiovascular Cohort-Second Manifestations of ARTerial disease-Studygroup (UCC-SMART Study Group): F.W. Asselbergs and H.M. Nathoe, Department of Cardiology; G.J. de Borst, Department of Vascular Surgery; M.L. Bots and M.I. Geerlings, Julius Center for health Sciences and Primary Care; M.H. Emmelot, Department of Geriatrics; P.A. de Jong and T. Leiner, Department of Radiology; A.T. Lely, Department of Obstetrics & Gynecology; N.P. van der Kaaij, Department of Cardiothoracic Surgery; L.J. Kappelle and Y.M. Ruigrok, Department of Neurology; M.C. Verhaar, Department of Nephrology, F.L.J. Visseren (chair) and J. Westerink, Department of Vascular Medicine, University Medical Center Utrecht and Utrecht University. Publisher Copyright: © 2022
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