Positron Emission Tomography to Improve Assessment of Interstitial Lung Disease in Patients With Systemic Sclerosis Eligible for Autologous Stem Cell Transplantation
Broens, Bo; van der Laken, Conny J; Zwezerijnen, Gerben J C; Nossent, Esther J; Meijboom, Lilian J; Spierings, Julia; de Vries-Bouwstra, Jeska K; van Laar, Jacob M; Voskuyl, Alexandre E
(2022) Frontiers in Immunology, volume 13
(Article)
Abstract
Positron emission tomography (PET) is a promising technique to improve the assessment of systemic sclerosis associated interstitial lung disease (SSc-ILD). This technique could be of particular value in patients with severe diffuse cutaneous SSc (dcSSc) that are possibly eligible for autologous hematopoietic stem cell transplantation (aHSCT). aHSCT is a potentially
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effective therapy for patients with severe dcSSc and ILD, leading to stabilization or improvement of lung function. However, there is a high need to improve patient selection, which includes (1) the selection of patients with rapidly progressive ILD for early rather than last-resort aHSCT (2) the prediction of treatment response on ILD and (3) the understanding of the mechanism(s) of action of aHSCT in the lungs. As previous studies with 18F-FDG PET in SSc-ILD and other forms of ILD have demonstrated its potential value in predicting disease progression and reactivity to anti-inflammatory treatment, we discuss the potential benefit of using this technique in patients with early severe dcSSc and ILD in the context of aHSCT. In addition, we discuss the potential value of other PET tracers in the assessment of ILD and understanding the mechanisms of action of aHSCT in the lung. Finally, we provide several suggestions for future research.
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Keywords: Hematopoietic Stem Cell Transplantation, Humans, Lung Diseases, Interstitial/complications, Positron-Emission Tomography, Scleroderma, Systemic/complications, Transplantation, Autologous, systemic sclerosis, interstitial lung disease, scleroderma, stem cell transplantation, positron emission tomography, lung fibrosis, Immunology and Allergy, Immunology, Journal Article
ISSN: 1664-3224
Publisher: Frontiers Media S. A.
Note: Funding Information: Boehringer Ingelheim and the Dutch Arthritis Society (under grant number 21-1-201) (partially) funded the F-FDG PET-CT study within the UPSIDE study. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication. 18 Publisher Copyright: Copyright © 2022 Broens, van der Laken, Zwezerijnen, Nossent, Meijboom, Spierings, de Vries-Bouwstra, van Laar and Voskuyl.
(Peer reviewed)