Note: Funding Information: Funding: The UCC-CVRM is primarily financed by the UMC Utrecht . A grant from The Netherlands Organization for Health Research and Development (# 8480-34001 ) was obtained to develop feedback procedures. UCC_CVRM website: www.umcutrecht.nl/ucc (in Dutch). Contact information UCC-CVRM: ucc@umcutrecht.nl . This work is partly supported by the EU/EFPIA Innovative Medicines Initiative 2 Joint Undertaking BigData@Heart grant n 116074 . R.v.d.G. and M.d.V. are funded by the ZonMw ETHMIRE study, grant number 91217027 .