Is early menopause a potential criterion for cardiovascular risk screening to detect high risk in a multi-ethnic population?: The Helius study
Reilingh, A Y A M; van den Meiracker, T R M; Bolijn, R; Galenkamp, H; Moll van Charante, E P; van der Schouw, Y T; van Valkengoed, I G M
(2022) Maturitas, volume 162, pp. 1 - 7
(Article)
Abstract
BACKGROUND: Women at risk of cardiovascular disease (CVD) may be missed with current eligibility criteria for CVD risk screening, particularly those from ethnic minority groups, among whom high risk is prevalent at a younger age. Early menopause (EM; menopause before 45 years) is associated with increased risk of CVD, and
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may be a potential eligibility criterion for CVD risk screening. AIMS AND OBJECTIVES: To determine the contribution of EM to current criteria from patient history (having a family history of CVD, current smoking, obesity and age over 50 years) for identifying women eligible for CVD risk screening in a multi-ethnic population. METHODS AND RESULTS: We used baseline data (2011-2015) from 4512 women aged 45-70 years of Dutch, South-Asian Surinamese, African Surinamese, Ghanaian, Turkish and Moroccan ethnic origin from the HELIUS study (Amsterdam, Netherlands). Models based on current eligibility criteria with and without EM were compared on area under the curve (AUC) with regard to estimated 10-year CVD risk using the Dutch SCORE. Overall, models with EM had a higher AUC, but changes were not statistically significant. In our total sample of women aged between 45 and 70 years, the AUC changed from 0.70 (95%CI 0.69-0.72) to 0.71 (95%CI 0.69-0.72). Among women aged 45-50 years the AUC changed from 0.66 (95%CI 0.58-0.74) to 0.68 (95%CI 0.59-0.74). Results were consistent across ethnic groups. CONCLUSIONS: The addition of EM to current eligibility criteria did not improve the detection of women at high CVD risk in a multi-ethnic sample of women aged 45-70 years.
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Keywords: Cardiovascular risk screening, Early menopause, Ethnic groups, HELIUS study, Primary prevention, SCORE, General Biochemistry,Genetics and Molecular Biology, Obstetrics and Gynaecology
ISSN: 0378-5122
Publisher: Elsevier Ireland Ltd
Note: Funding Information: The study reported was supported by a grant from ZonMw (grant number 849200008 ). Moreover, the HELIUS study is conducted by the Amsterdam University Medical Centers, location AMC and the Public Health Service of Amsterdam. Both organisations provided core support for HELIUS. The HELIUS study is also funded by the Dutch Heart Foundation (grant number 2010T084 , K. Stronks), the Netherlands Organization for Health Research and Development ((ZonMw, grant number 200500003 ), the European Union (FP-7, grant number 278901 , K. Stronks), and the European Fund for the Integration of non-EU immigrants (EIF, grant number 278901, K. Stronks). Funding Information: The study reported was supported by a grant from ZonMw (grant number 849200008). Moreover, the HELIUS study is conducted by the Amsterdam University Medical Centers, location AMC and the Public Health Service of Amsterdam. Both organisations provided core support for HELIUS. The HELIUS study is also funded by the Dutch Heart Foundation (grant number 2010T084, K. Stronks), the Netherlands Organization for Health Research and Development (ZonMw, grant number 200500003 ), the European Union (FP-7, grant number 278901 , K. Stronks), and the European Fund for the Integration of non-EU immigrants (EIF, grant number 278901, K. Stronks). We are most grateful to the participants of the HELIUS study and the management team, research nurses, interviewers, research assistants and other staff who have taken part in gathering the data of this study. We thank Dr. Ineke van Dis for providing the conversions for the Dutch SCORE algorithm and Dr. Wilco Perini for sharing his insights generously. Funding Information: The study reported was supported by a grant from ZonMw (grant number 849200008). Moreover, the HELIUS study is conducted by the Amsterdam University Medical Centers, location AMC and the Public Health Service of Amsterdam. Both organisations provided core support for HELIUS. The HELIUS study is also funded by the Dutch Heart Foundation (grant number 2010T084, K. Stronks), the Netherlands Organization for Health Research and Development ((ZonMw, grant number 200500003), the European Union (FP-7, grant number 278901, K. Stronks), and the European Fund for the Integration of non-EU immigrants (EIF, grant number 278901, K. Stronks).The study reported was supported by a grant from ZonMw (grant number 849200008). Moreover, the HELIUS study is conducted by the Amsterdam University Medical Centers, location AMC and the Public Health Service of Amsterdam. Both organisations provided core support for HELIUS. The HELIUS study is also funded by the Dutch Heart Foundation (grant number 2010T084, K. Stronks), the Netherlands Organization for Health Research and Development (ZonMw, grant number 200500003), the European Union (FP-7, grant number 278901, K. Stronks), and the European Fund for the Integration of non-EU immigrants (EIF, grant number 278901, K. Stronks). We are most grateful to the participants of the HELIUS study and the management team, research nurses, interviewers, research assistants and other staff who have taken part in gathering the data of this study. We thank Dr. Ineke van Dis for providing the conversions for the Dutch SCORE algorithm and Dr. Wilco Perini for sharing his insights generously. Publisher Copyright: © 2022 The Author(s)
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