Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification

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Troy/Tnfrsf19 marks epidermal cells that govern interfollicular epidermal renewal and cornification
 
Kretzschmar, Kai; Boonekamp, Kim E.; Bleijs, Margit; Asra, Priyanca; Koomen, Mandy; Chuva de Sousa Lopes, Susana M.; Giovannone, Barbara; Clevers, Hans
(2021) Stem Cell Reports, volume 16, issue 9, pp. 2379 - 2394
(Article)
Abstract
The skin epidermis is a highly compartmentalized tissue consisting of a cornifying epithelium called the interfollicular epidermis (IFE) and associated hair follicles (HFs). Several stem cell populations have been described that mark specific compartments in the skin but none of them is specific to the IFE. Here, we identify Troy ... read more
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Keywords: epidermis, lineage tracing, organoids, single-cell transcriptomics, stem cells, Tnfrsf19, Troy, Biochemistry, Genetics, Developmental Biology, Cell Biology
DOI: https://doi.org/10.1016/j.stemcr.2021.07.007
ISSN: 2213-6711
Publisher: Cell Press
Note: Funding Information: We thank Onur Basak, Johan van Es and Maaike van den Born for experimental assistance; Stefan van der Elst and Reinier van den Linden for help with flow cytometry; the Utrecht Sequencing Facility (USEQ) for sequencing; Anna Alemany Arias for help with bioinformatics analysis and Anko de Graaff and the Hubrecht Imaging Centre (HIC) for assistance with microscopy. We thank the Gynaikon Clinic in Rotterdam for the efforts in providing the fetal material. This work was supported by a Sinergia grant from the Swiss National Science Foundation (SNSF/ CRSII3 160738-1 , to H.C.) and by a German Cancer Aid grant (via MSNZ Würzburg, to K.K.). K.K. was recipient of a VENI grant from the Netherlands Organisation for Scientific Research (NWO-ZonMW, 016.166.140 ) and was a long-term fellow of the Human Frontier Science Program Organization (HFSPO, LT771/2015 ). Funding Information: We thank Onur Basak, Johan van Es and Maaike van den Born for experimental assistance; Stefan van der Elst and Reinier van den Linden for help with flow cytometry; the Utrecht Sequencing Facility (USEQ) for sequencing; Anna Alemany Arias for help with bioinformatics analysis and Anko de Graaff and the Hubrecht Imaging Centre (HIC) for assistance with microscopy. We thank the Gynaikon Clinic in Rotterdam for the efforts in providing the fetal material. This work was supported by a Sinergia grant from the Swiss National Science Foundation (SNSF/CRSII3 160738-1, to H.C.) and by a German Cancer Aid grant (via MSNZ W?rzburg, to K.K.). K.K. was recipient of a VENI grant from the Netherlands Organisation for Scientific Research (NWO-ZonMW, 016.166.140) and was a long-term fellow of the Human Frontier Science Program Organization (HFSPO, LT771/2015). Publisher Copyright: © 2021 The Authors
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