Neisseria meningitidis Serogroup Z Meningitis in a Child with Complement C8 Deficiency and Potential Cross Protection of the MenB-4C Vaccine

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Neisseria meningitidis Serogroup Z Meningitis in a Child with Complement C8 Deficiency and Potential Cross Protection of the MenB-4C Vaccine
 
Van Den Broek, Bryan; Coolen, Jordy P.M.; De Jonge, Marien I.; De Groot, Ronald; Henriet, Stefanie S.V.; Langereis, Jeroen D.; Van Der Flier, Michiel
(2021) Pediatric Infectious Disease Journal, volume 40, issue 11, pp. 1019 - 1022
(Article)
Abstract
Complement deficient patients are susceptible to rare meningococcal serogroups. A 6-year-old girl presented with serogroup Z meningitis. This led to identification of a C8 deficiency. The MenB-4C vaccine induced cross-reactive antibodies to serogroup Z and increased in vitro opsonophagocytic killing and may thus protect complement deficient patients.
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Keywords: complement deficiency, immune compromised, MenB-4C, Neisseria meningitidis, vaccine, Pediatrics, Perinatology, and Child Health, Microbiology (medical), Infectious Diseases
DOI: https://doi.org/10.1097/INF.0000000000003259
ISSN: 0891-3668
Publisher: Lippincott Williams and Wilkins
Note: Publisher Copyright: © 2021 Lippincott Williams and Wilkins. All rights reserved.
(Peer reviewed)