Source-specific host response and outcomes in critically ill patients with sepsis: a prospective cohort study

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Source-specific host response and outcomes in critically ill patients with sepsis: a prospective cohort study
 
MARS Consortium
(2022) Intensive Care Medicine, volume 48, issue 1, pp. 92 - 102
(Article)
Abstract
Purpose: There is limited knowledge on how the source of infection impacts the host response to sepsis. We aimed to compare the host response in sepsis patients with a single, known source at admission (< 24 h) to the intensive care unit. Methods: From the molecular diagnosis and risk stratification of ... read more
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Keywords: Host response, Intensive care unit, Sepsis, Site of infection, Source of infection, Critical Care and Intensive Care Medicine
DOI: https://doi.org/10.1007/s00134-021-06574-0
ISSN: 0342-4642
Publisher: Springer-Verlag
Note: Funding Information: This research was performed within the framework of the Center for Translational Molecular Medicine (CTMM) ( www.ctmm.nl ), project Molecular Diagnosis and Risk Stratification of Sepsis (Grant 04I-201). H.P.S. was supported by the Dutch Kidney Foundation (Kolff Grant Nr. 19OK009). J.M.B. was supported by the European Commission (Horizon 2020, ImmunoSep, Grant number 847422). L.A.v.V. was supported by a VENI grant from ZonMW (Grant number 09150161910033). Members of MARS consortium are: Departments of Intensive Care Medicine, Amsterdam University Medical Centers, location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands: Friso M. de Beer, MD, Lieuwe D. J. Bos, PhD, Gerie J. Glas, MD, Roosmarijn T. M. van Hooijdonk, MD, Janneke Horn, MD, Laura R. A. Schouten, MD, Marleen Straat, MD, Luuk Wieske, MD, Esther Witteveen, MD. Center for Experimental and Molecular Medicine, Amsterdam University Medical Centers, location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, and Center of Infection and Immunity Amsterdam (CINIMA), Amsterdam University Medical Centers, location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Tom D.Y. Reijnders, MD, Alex R. Schuurman, MD, Tjitske S.R. van Engelen, MD, Liza Pereverzeva, MD, Arie J. Hoogendijk, PhD, Mischa A. Huson, MD, Maryse A. Wiewel, MD; Department of Medical Microbiology, Department of Intensive Care Medicine, and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands; Peter M.C. Klein Klouwenberg, MD, David S.Y. Ong, MD; Department of Intensive Care Medicine and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands; Jos F. Frencken, MD, Maria E. Koster-Brouwer, MSc, Kirsten van de Groep, MD, Diana M. Verboom, MD. Funding Information: This research was performed within the framework of the Center for Translational Molecular Medicine (CTMM) (www.ctmm.nl ), project Molecular Diagnosis and Risk Stratification of Sepsis (Grant 04I-201). H.P.S. was supported by the Dutch Kidney Foundation (Kolff Grant Nr. 19OK009). J.M.B. was supported by the European Commission (Horizon 2020, ImmunoSep, Grant number 847422). L.A.v.V. was supported by a VENI grant from ZonMW (Grant number 09150161910033). Members of MARS consortium are: Departments of Intensive Care Medicine, Amsterdam University Medical Centers, location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands: Friso M. de Beer, MD, Lieuwe D. J. Bos, PhD, Gerie J. Glas, MD, Roosmarijn T. M. van Hooijdonk, MD, Janneke Horn, MD, Laura R. A. Schouten, MD, Marleen Straat, MD, Luuk Wieske, MD, Esther Witteveen, MD. Center for Experimental and Molecular Medicine, Amsterdam University Medical Centers, location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, and Center of Infection and Immunity Amsterdam (CINIMA), Amsterdam University Medical Centers, location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Tom D.Y. Reijnders, MD, Alex R. Schuurman, MD, Tjitske S.R. van Engelen, MD, Liza Pereverzeva, MD, Arie J. Hoogendijk, PhD, Mischa A. Huson, MD, Maryse A. Wiewel, MD; Department of Medical Microbiology, Department of Intensive Care Medicine, and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands; Peter M.C. Klein Klouwenberg, MD, David S.Y. Ong, MD; Department of Intensive Care Medicine and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands; Jos F. Frencken, MD, Maria E. Koster-Brouwer, MSc, Kirsten van de Groep, MD, Diana M. Verboom, MD. Publisher Copyright: © 2021, The Author(s).
(Peer reviewed)