Note: Funding Information: Funding: this investigation was supported by a Bas Mulder Award to VP from the Dutch Cancer Foundation (KWF)/Alped’HuZes foundation (award no. UU 2015-7663) and a project grant to VP from the Dutch Cancer Foundation (KWF)/Alped’HuZes foundation (grant no. 11108). MC was supported in part by a postdoctoral grant from the Ramón Areces Foundation.