Glanzmann thrombasthenia complicated by frequent myeloproliferative neoplasm-related thromboembolism: thrombosis occurring regardless of αIIbβIII integrin deficiency

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Glanzmann thrombasthenia complicated by frequent myeloproliferative neoplasm-related thromboembolism: thrombosis occurring regardless of αIIbβIII integrin deficiency
 
Schutgens, Roger E.G.; Urbanus, Rolf T.
(2021) Clinical case reports, volume 9, issue 9, pp. 1 - 3
(Article)
Abstract
A patient with Glanzmann Thrombasthenia developed recurrent venous thrombosis with a JAK2 positive myeloproliferative neoplasm. This indicates that the platelet aIIbβIII integrin has no role in venous thrombosis. We discuss the other potential mechanisms that are involved. In addition, we describe the successful use of dabigatran in this patient.
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Keywords: dabigatran, Glanzmann thrombasthenia, myeloproliferative neoplasm, platelet, venous thrombosis, αIIbβIII integrin, alpha IIb beta III integrin, General Medicine, Case Reports
DOI: https://doi.org/10.1002/ccr3.4757
ISSN: 2050-0904
Publisher: John Wiley and Sons Ltd
Note: Funding Information: Informed consent was obtained from the patient. Publisher Copyright: © 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. © 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.
(Peer reviewed)