T-cell subsets in the skin and their role in inflammatory skin disorders
Kortekaas Krohn, Inge; Aerts, Joeri L; Breckpot, Karine; Goyvaerts, Cleo; Knol, Edward; Van Wijk, Femke; Gutermuth, Jan
(2022) Allergy, volume 77, issue 3, pp. 827 - 842
(Article)
Abstract
T lymphocytes (T-cells) are major players of the adaptive immune response. Naive T-cells are primed in the presence of cytokines, leading to polarization into distinct T-cell subsets with specific functions. These subsets are classified based on their T-cell receptor profile, expression of transcription factors, surface cytokine and chemokine receptors, and
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their cytokine production, which together determine their specific function. This review provides an overview of the various T-cell subsets and their function in several inflammatory skin disorders ranging from allergic inflammation to skin tumors. Moreover, we highlight similarities of T-cell responses across different skin disorders, demonstrating the presence of similar and opposing functions for the different T-cell subsets. Finally, we discuss the effects of currently available and promising therapeutic approaches to harness T-cells in inflammatory skin diseases for which efficacy next to unwanted side-effects provide new insights into the pathophysiology of skin disorders.
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Keywords: inflammatory skin disorders, skin diseases, T cells, T-cell subsets, Immunology and Allergy, Immunology, Review, Journal Article
ISSN: 0105-4538
Publisher: Wiley-Blackwell
Note: Funding Information: IKK is holder of the Fonds Wetenschappelijk Onderzoek (FWO) Post‐Doctoral mandate (12W2219N) and a “Type 2 Innovative Grant” (2018) from Sanofi Genzyme. JG received research grants and/or served as advisor/speaker for Janssen, Sanofi, LEO Pharma, Mylan, Lilly, Abbvie, and Pfizer. He is member of the Advisory Board of Sanofi. KB holds a young investigator award of the Melanoma Research Alliance (grant number 509516, grant identifier https://doi.org/10.48050/pc.gr.75694 . FW received research grants and/or served as advisor/speaker for Johnson & Johnson, Sanofi, LEO Pharma, Takeda. Publisher Copyright: © 2021 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
(Peer reviewed)