Visceral Adipose Tissue and Different Measures of Adiposity in Different Severities of Diffuse Idiopathic Skeletal Hyperostosis
Harlianto, Netanja I; Westerink, Jan; Foppen, Wouter; Hol, Marjolein E; Wittenberg, Rianne; van der Veen, Pieternella H; van Ginneken, Bram; Kuperus, Jonneke S; Verlaan, Jorrit-Jan; de Jong, Pim A; Mohamed Hoesein, Firdaus A A; On Behalf Of The Ucc-Smart-Study Group
(2021) Journal of Personalized Medicine, volume 11, issue 7
(Article)
Abstract
BACKGROUND: Diffuse idiopathic skeletal hyperostosis (DISH) is associated with both obesity and type 2 diabetes. Our objective was to investigate the relation between DISH and visceral adipose tissue (VAT) in particular, as this would support a causal role of insulin resistance and low grade inflammation in the development of DISH.
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METHODS: In 4334 patients with manifest vascular disease, the relation between different adiposity measures and the presence of DISH was compared using z-scores via standard deviation logistic regression analyses. Analyses were stratified by sex and adjusted for age, systolic blood pressure, diabetes, non-HDL cholesterol, smoking status, and renal function. RESULTS: DISH was present in 391 (9%) subjects. The presence of DISH was associated with markers of adiposity and had a strong relation with VAT in males (OR: 1.35; 95%CI: 1.20-1.54) and females (OR: 1.43; 95%CI: 1.06-1.93). In males with the most severe DISH (extensive ossification of seven or more vertebral bodies) the association between DISH and VAT was stronger (OR: 1.61; 95%CI: 1.31-1.98), while increased subcutaneous fat was negatively associated with DISH (OR: 0.65; 95%CI: 0.49-0.95). In females, increased subcutaneous fat was associated with the presence of DISH (OR: 1.43; 95%CI: 1.14-1.80). CONCLUSION: Markers of adiposity, including VAT, are strongly associated with the presence of DISH. Subcutaneous adipose tissue thickness was negatively associated with more severe cases of DISH in males, while in females, increased subcutaneous adipose tissue was associated with the presence of DISH.
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Keywords: adiposity, diffuse idiopathic skeletal hyperostosis, intra-abdominal fat, risk factors, Intra-abdominal fat, Diffuse idiopathic skeletal hyperostosis, Adiposity, Risk factors, Medicine (miscellaneous), Journal Article
ISSN: 2075-4426
Publisher: MDPI Multidisciplinary Digital Publishing Institute
Note: Funding Information: Funding: The UCC-SMART study was financially supported by a grant from the University Medical Center Utrecht. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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