Minimizing complications in a porcine survival craniotomy model
Kinaci, Ahmet; Vaessen, Koen; Redegeld, Saskia; van der Zwan, Albert; van Doormaal, Tristan P.C.
(2021) Laboratory Animals, volume 55, issue 5, pp. 435 - 442
(Article)
Abstract
A large craniotomy survival porcine model is useful for scientific research. The surgical approaches and complications of craniotomies in pigs have not been published before. This study describes how large craniotomies were performed in 46 pigs and how the risk of complications was minimized. The major complications were direct postoperative
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epidural hematomas (n = 3) and sagittal sinus rupture (n = 4). The measures taken to prevent postoperative epidural hematomas consisted of optimizing anesthesia, using bone wax to stop trabecular bleeding, increasing blood pressure before bone flap replacement, tranexamic acid administration, and postoperative recovery of the pigs in the prone position in a dedicated hammock. After these measures, no pig died from a postoperative epidural hematoma. Iatrogenic sagittal sinus rupture occurred in cases where the dura shifted into the craniotome during craniotomy. The dura was detached from the skull through drill holes with custom elevators before craniotomy to minimize the risk of a sagittal sinus rupture. In conclusion, pigs can undergo craniotomy and survive if the right measures are put in place.
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Keywords: animal research, craniotomy, in vivo model, Neurosurgery, pig model, Animal Science and Zoology, General Veterinary
ISSN: 0023-6772
Publisher: SAGE Publications Ltd
Note: Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: the study was partially funded by Polyganics BV, Groningen, The Netherlands. Funding Information: The authors would like to thank S. van Thoor BSc, Quality Manager of Brain Technology Institute, Utrecht, The Netherlands, for technical support and quality control. The authors acknowledge the encouragement, advice and constructive criticism of K. S. Han of the Department of Neurology and Neurosurgery Brain Center Rudolph Magnus, University Medical Centre Utrecht, The Netherlands. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: the study was partially funded by Polyganics BV, Groningen, The Netherlands. Publisher Copyright: © The Author(s) 2021.
(Peer reviewed)