Novel Orally Formulated Mixed Micelles Optimize Vitamin K Absorption Under Bile-Deficient Conditions

Rooimans, Thijs; Minderhoud, Tanca; Leal, Nerea; Vromans, Herman; van Nostrum, Cornelus; van Hasselt, Peter; Rodriguez, M.; Sun, F.; Oussoren, C.; Slot, T. K.; van der Ham, M.; Janssens, G. E.P.J.; de Sain-van der Velden, M. G.M.; Houwen, R. H.J.; de Koning, T. J.; Hennink, W. E.; Lipophilic Drug Delivery Despite Cholestasis Study Group

doi:https://doi.org/10.1053/j.gastro.2021.05.056

Novel Orally Formulated Mixed Micelles Optimize Vitamin K Absorption Under Bile-Deficient Conditions

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Novel Orally Formulated Mixed Micelles Optimize Vitamin K Absorption Under Bile-Deficient Conditions

Rooimans, Thijs; Minderhoud, Tanca; Leal, Nerea; Vromans, Herman; van Nostrum, Cornelus; van Hasselt, Peter; Rodriguez, M.; Sun, F.; Oussoren, C.; Slot, T. K.; van der Ham, M.; Janssens, G. E.P.J.; de Sain-van der Velden, M. G.M.; Houwen, R. H.J.; de Koning, T. J.; Hennink, W. E.; Lipophilic Drug Delivery Despite Cholestasis Study Group

(2021) Gastroenterology, volume 161, issue 3, pp. 1056 - 1059.e5

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Keywords: Administration, Oral, Animals, Antifibrinolytic Agents/administration & dosage, Bile/metabolism, Biological Availability, Cholestasis/metabolism, Disease Models, Animal, Drug Compounding, Gastrointestinal Absorption, Male, Micelles, Rats, Rats, Wistar, Vitamin K/administration & dosage, Journal Article

DOI: https://doi.org/10.1053/j.gastro.2021.05.056

ISSN: 0016-5085

Publisher: W.B. Saunders

(Peer reviewed)