Novel Orally Formulated Mixed Micelles Optimize Vitamin K Absorption Under Bile-Deficient Conditions

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Novel Orally Formulated Mixed Micelles Optimize Vitamin K Absorption Under Bile-Deficient Conditions
 
Rooimans, Thijs; Minderhoud, Tanca; Leal, Nerea; Vromans, Herman; van Nostrum, Cornelus; van Hasselt, Peter; Rodriguez, M.; Sun, F.; Oussoren, C.; Slot, T. K.; van der Ham, M.; Janssens, G. E.P.J.; de Sain-van der Velden, M. G.M.; Houwen, R. H.J.; de Koning, T. J.; Hennink, W. E.; Lipophilic Drug Delivery Despite Cholestasis Study Group
(2021) Gastroenterology, volume 161, issue 3, pp. 1056 - 1059.e5
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Keywords: Journal Article
DOI: https://doi.org/10.1053/j.gastro.2021.05.056
ISSN: 0016-5085
Publisher: W.B. Saunders Ltd
Note: Funding Information: Funding Financial support for this study was provided by Tiofarma BV. Funding Information: The authors acknowledge the skilled technical assistance of the microsurgery team (Central Laboratory Animal Research Facility, Utrecht University). CRediT Authorship ContributionsThijs Rooimans, MSc (Conceptualization: Lead; Data curation: Lead; Formal analysis: Lead; Investigation: Lead; Methodology: Lead; Software: Lead; Visualization: Lead; Writing ? original draft: Lead; Writing ? review & editing: Lead). Tanca Minderhoud, Dr (Data curation: Supporting; Formal analysis: Supporting; Investigation: Supporting; Methodology: Supporting; Writing ? original draft: Supporting; Writing ? review & editing: Supporting). Nerea Leal, Dr (Investigation: Supporting; Methodology: Supporting; Software: Supporting; Writing ? review & editing: Supporting). Herman Vromans, Prof Dr (Conceptualization: Supporting; Funding acquisition: Lead; Supervision: Equal; Writing ? review & editing: Supporting). Rene van Nostrum, Dr (Conceptualization: Supporting; Methodology: Supporting; Supervision: Supporting; Writing ? review & editing: Supporting). Peter Marin van Hasselt, Dr (Conceptualization: Lead; Data curation: Lead; Formal analysis: Supporting; Investigation: Supporting; Methodology: Lead; Supervision: Equal; Visualization: Supporting; Writing ? original draft: Supporting; Writing ? review & editing: Supporting). Funding Financial support for this study was provided by Tiofarma BV.
(Peer reviewed)