Can previous associations of single nucleotide polymorphisms in the tlr2, nod1, cxcr5, and il10 genes in the susceptibility to and severity of chlamydia trachomatis infections be confirmed?
Jukema, Jelmer B.; Hoenderboom, Bernice M.; Van Benthem, Birgit H.B.; Van Der Sande, Marianne A.B.; De Vries, Henry J.C.; Hoebe, Christian J.P.A.; Dukers-Muijrers, Nicole H.T.M.; Bax, Caroline J.; Morré, Servaas A.; Ouburg, Sander
(2021) Pathogens, volume 10, issue 1, pp. 1 - 16
(Article)
Abstract
Clear inter-individual differences exist in the response to C. trachomatis (CT) infections and reproductive tract complications in women. Host genetic variation like single nucleotide polymorphisms (SNPs) have been associated with differences in response to CT infection, and SNPsmight be used as a genetic component in a tubal-pathology predicting algorithm. Our
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aimwas to confirmthe role of four genes by investigating proven associated SNPs in the susceptibility and severity of a CT infection. A total of 1201 women fromfive cohorts were genotyped and analyzed for TLR2+2477 G>A, NOD1+32656 T→GG, CXCR5+10950 T>C, and IL10-1082 A>G. Results confirmed that NOD1+32656 T→GG was associated with an increased risk of a symptomatic CT infection (OR: 1.9, 95%CI: 1.1-3.4, p = 0.02), but we did not observe an association with late complications. IL10-1082 A>G appeared to increase the risk of late complications (i.e., ectopic pregnancy/tubal factor infertility) following a CT infection (OR=2.8, 95%CI: 1.1-7.1, p=0.02). Other associations were not found. Confirmatory studies are important, and large cohorts are warranted to further investigate SNPs’ role in the susceptibility and severity of a CT infection.
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Keywords: Chlamydia trachomatis, Severity, Single nucleotide polymorphism, SNP, Susceptibility, severity, susceptibility, single nucleotide polymorphism, Immunology and Allergy, Molecular Biology, General Immunology and Microbiology, Microbiology (medical), Infectious Diseases, Journal Article
Publisher: MDPI AG
Note: Funding Information: Funding: This study is funded by the Netherlands Organisation for Health Research and Development (ZonMW Netherlands, a governmental organization grant (registration number: 50-53000-98-103) and research funding from the Ministry of Health, Welfare and Sports to the Centre of Infectious Disease Control. Additional funding has been obtained for the SNP based analyses: The host genetic marker Assay used inside this Consortium is being developed via an EU Eurostars Grant entitled “The development of an accurate host genetic diagnostic assay for women with subfertility “(Acronym TubaTEST), Grant number E19372, awarded to TubaScan Ltd., a spin-off company of the VU University Medical Centre, Amsterdam, Department of Medical Microbiology and Infection Control, Laboratory of Immunogenetics. Funding Information: This study is funded by the Netherlands Organisation for Health Research and Development (ZonMW Netherlands, a governmental organization grant (registration number: 50-53000- 98-103) and research funding from the Ministry of Health, Welfare and Sports to the Centre of Infectious Disease Control. Additional funding has been obtained for the SNP based analyses: The host genetic marker Assay used inside this Consortium is being developed via an EU Eurostars Grant entitled ?The development of an accurate host genetic diagnostic assay for women with subfertility ?(Acronym TubaTEST), Grant number E19372, awarded to TubaScan Ltd., a spin-off company of the VU University Medical Centre, Amsterdam, Department of Medical Microbiology and Infection Control, Laboratory of Immunogenetics. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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