Fast and accurate modeling of transient-state, gradient-spoiled sequences by recurrent neural networks

Abstract

Fast and accurate modeling of MR signal responses are typically required for various quantitative MRI applications, such as MR fingerprinting. This work uses a new extended phase graph (EPG)-Bloch model for accurate simulation of transient-state, gradient-spoiled MR sequences, and proposes a recurrent neural network (RNN) as a fast surrogate of the EPG-Bloch model for computing large-scale MR signals and derivatives. The computational efficiency of the RNN model is demonstrated by comparisons with other existing models, showing one to three orders of acceleration compared with the latest GPU-accelerated, open-source EPG package. By using numerical and in vivo brain data, two used cases, namely, MRF dictionary generation and optimal experimental design, are also provided. Results show that the RNN surrogate model can be efficiently used for computing large-scale dictionaries of transient-state signals and derivatives within tens of seconds, resulting in several orders of magnitude acceleration with respect to state-of-the-art implementations. The practical application of transient-state quantitative techniques can therefore be substantially facilitated.