Hypothermic Machine Perfusion as a National Standard Preservation Method for Deceased Donor Kidneys
Brat, Aukje; de Vries, Kirsten M; van Heurn, Ernst W E; Huurman, Volkert A L; de Jongh, Wim; Leuvenink, Henri G D; van Zuilen, Arjan D; Haase-Kromwijk, Bernadette J J M; de Jonge, Jeroen; Berger, Stefan P; Hofker, Sijbrand H
(2022) Transplantation, volume 106, issue 5, pp. 1043 - 1050
(Article)
Abstract
Background. Recently, continuous nonoxygenated hypothermic machine perfusion (HMP) has been implemented as standard preservation method for deceased donor kidneys in the Netherlands. This study was designed to assess the effect of the implementation of HMP on early outcomes after transplantation. Methods. Kidneys donated in the Netherlands in 2016 and 2017
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were intended to be preserved by HMP. A historical cohort (2010-2014) preserved by static cold storage was chosen as the control group. Primary outcome was delayed graft function (DGF). Additional analyses were performed on safety, graft function, and survival up until 2 y after transplantation. Results. Data were collected on 2493 kidneys. Analyses showed significantly more donation after circulatory death, preemptive transplantation, and retransplants in the project cohort. Of the 681 kidneys that were transplanted during the project, 81% were preserved by HMP. No kidneys were discarded due to HMP-related complications. DGF occurred in 38.2% of the project cohort versus 43.7% of the historical cohort (P < 0.001), with a significantly shorter duration within the project cohort (7 versus 9 d, P = 0.003). Multivariate regression analysis showed an odds ratio of 0.69 (95% confidence interval, 0.553-0.855) for the risk of DGF when using HMP compared with cold storage (P = 0.001). There was no significant difference in kidney function, graft survival, and recipient survival up until 2 y posttransplantation. Conclusions. This study showed that HMP as a standard preservation method for deceased donor kidneys is safe and feasible. HMP was associated with a significant reduction of DGF.
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Keywords: Delayed Graft Function/etiology, Humans, Kidney, Kidney Transplantation/methods, Organ Preservation/adverse effects, Perfusion/adverse effects, Tissue Donors, Transplantation, Journal Article
ISSN: 0041-1337
Publisher: Lippincott Williams & Wilkins
Note: Funding Information: The logistical service was adapted from the randomized controlled trial COPE COMPARE. In this RCT, only 2 perfusion hubs were operational to offer support at the donation and transplant sites. In March of 2017, the number of perfusion hubs was increased to 3, allowing a more efficient coverage of the country. Initially, both procuring and transplant teams were supported on-site by the TTs from the perfusion hubs. To reduce costs, local TTs were introduced, being responsible for assisting the transplant team and returning the machines to the perfusion hub by regular courier service. Publisher Copyright: © 2022 Lippincott Williams and Wilkins. All rights reserved.
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