Cortical gray matter reduction precedes transition to psychosis in individuals at clinical high-risk for psychosis: A voxel-based meta-analysis
Fortea, Adriana; Batalla, Albert; Radua, Joaquim; van Eijndhoven, Philip; Baeza, Inmaculada; Albajes-Eizagirre, Anton; Fusar-Poli, Paolo; Castro-Fornieles, Josefina; De la Serna, Elena; Luna, Licia P.; Carvalho, André F.; Vieta, Eduard; Sugranyes, Gisela
(2021) Schizophrenia Research, volume 232, pp. 98 - 106
(Article)
Abstract
Gray matter and cortical thickness reductions have been documented in individuals at clinical high-risk for psychosis and may be more pronounced in those who transition to psychosis. However, these findings rely on small samples and are inconsistent across studies. In this review and meta-analysis we aimed to investigate neuroanatomical correlates
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of clinical high-risk for psychosis and potential predictors of transition, using a novel meta-analytic method (Seed-based d Mapping with Permutation of Subject Images) and cortical mask, combining data from surface-based and voxel-based morphometry studies. Individuals at clinical high-risk for psychosis who later transitioned to psychosis were compared to those who did not and to controls, and included three statistical maps. Overall, individuals at clinical high-risk for psychosis did not differ from controls, however, within the clinical high-risk for psychosis group, transition to psychosis was associated with less cortical gray matter in the right temporal lobe (Hedges' g = −0.377), anterior cingulate and paracingulate (Hedges' g = −0.391). These findings have the potential to help refine prognostic and etiopathological research in early psychosis.
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Keywords: Clinical high-risk for psychosis, Cortical thickness, Early psychosis, Meta-analysis, Neuroimaging, VBM, Psychiatry and Mental health, Biological Psychiatry
ISSN: 0920-9964
Publisher: Elsevier
Note: Funding Information: This work was supported by the Fundació Clínic Recerca Biomèdica (Ajut a la Recerca Pons Bartran), the Brain and Behavior Research Foundation (NARSAD Young Investigator Award 2017, grant ID: 26731 ), the Alicia Koplowitz Foundation ( AKOPLOWITZ20_004 ) and the Spanish Ministry of Health, Instituto de Salud Carlos III “Health Research Fund” ( PI15/0444 ; PI18/0242 ; PI18/00976 ; INT19/00021 ). FEDER “Otra manera de hacer Europa”. Funding Information: This work was supported by the Fundaci? Cl?nic Recerca Biom?dica (Ajut a la Recerca Pons Bartran), the Brain and Behavior Research Foundation (NARSAD Young Investigator Award 2017, grant ID: 26731), the Alicia Koplowitz Foundation (AKOPLOWITZ20_004) and the Spanish Ministry of Health, Instituto de Salud Carlos III ?Health Research Fund? (PI15/0444; PI18/0242; PI18/00976; INT19/00021). FEDER ?Otra manera de hacer Europa?. Publisher Copyright: © 2021 Elsevier B.V.
(Peer reviewed)