Metabolic Age Based on the BBMRI-NL 1H-NMR Metabolomics Repository as Biomarker of Age-related Disease
van den Akker, Erik B; Trompet, Stella; Barkey Wolf, Jurriaan J H; Beekman, Marian; Suchiman, H Eka D; Deelen, Joris; Asselbergs, Folkert W; Boersma, Eric; Cats, Davy; Elders, Petra M; Geleijnse, J Marianne; Ikram, M Arfan; Kloppenburg, Margreet; Mei, Haillang; Meulenbelt, Ingrid; Mooijaart, Simon P; Nelissen, Rob G H H; Netea, Mihai G; Penninx, Brenda W J H; Slofstra, Mariska; Stehouwer, Coen D A; Swertz, Morris A; Teunissen, Charlotte E; Terwindt, Gisela M; 't Hart, Leen M; van den Maagdenberg, Arn M J M; van der Harst, Pim; van der Horst, Iwan C C; van der Kallen, Carla J H; van Greevenbroek, Marleen M J; van Spil, W Erwin; Wijmenga, Cisca; Zhernakova, Alexandra; Zwinderman, Aeilko H; Sattar, Naveed; Jukema, J Wouter; van Duijn, Cornelia M; Boomsma, Dorret I; Reinders, Marcel J T; Slagboom, P Eline
(2020) Circulation. Genomic and precision medicine, volume 13, issue 5, pp. 541 - 547
(Article)
Abstract
BACKGROUND: The blood metabolome incorporates cues from the environment and the host's genetic background, potentially offering a holistic view of an individual's health status. METHODS: We have compiled a vast resource of proton nuclear magnetic resonance metabolomics and phenotypic data encompassing over 25 000 samples derived from 26 community and hospital-based
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cohorts. RESULTS: Using this resource, we constructed a metabolomics-based age predictor (metaboAge) to calculate an individual's biological age. Exploration in independent cohorts demonstrates that being judged older by one's metabolome, as compared with one's chronological age, confers an increased risk on future cardiovascular disease, mortality, and functionality in older individuals. A web-based tool for calculating metaboAge (metaboage.researchlumc.nl) allows easy incorporation in other epidemiological studies. Access to data can be requested at bbmri.nl/samples-images-data. CONCLUSIONS: In summary, we present a vast resource of metabolomics data and illustrate its merit by constructing a metabolomics-based score for biological age that captures aspects of current and future cardiometabolic health.
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Keywords: Aging, Cardiovascular disease, Data science, Metabolomics, Genetics, Cardiology and Cardiovascular Medicine, Genetics(clinical)
ISSN: 2574-8300
Publisher: Lippincott Williams and Wilkins Ltd.
Note: Publisher Copyright: © 2020 American Heart Association, Inc. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
(Peer reviewed)