Sex Differences in the Risk of Coronary Heart Disease Associated With Type 2 Diabetes: A Mendelian Randomization Analysis

DSpace/Manakin Repository

Sex Differences in the Risk of Coronary Heart Disease Associated With Type 2 Diabetes: A Mendelian Randomization Analysis
 
Peters, Tricia M; Holmes, Michael V; Richards, J Brent; Palmer, Tom; Forgetta, Vincenzo; Lindgren, Cecilia M; Asselbergs, Folkert W; Nelson, Christopher P; Samani, Nilesh J; McCarthy, Mark I; Mahajan, Anubha; Davey Smith, George; Woodward, Mark; O'Keeffe, Linda M; Peters, Sanne A E
(2021) Diabetes Care, volume 44, issue 2, pp. 556 - 562
(Article)
Abstract
OBJECTIVE: Observational studies have demonstrated that type 2 diabetes is a stronger risk factor for coronary heart disease (CHD) in women compared with men. However, it is not clear whether this reflects a sex differential in the causal effect of diabetes on CHD risk or results from sex-specific residual confounding. ... read more
Download/Full Text
The full text of this publication is not available.
Version on publisher website for UU-students and staff
Version on publisher website
 
Keywords: Internal Medicine, Endocrinology, Diabetes and Metabolism, Advanced and Specialised Nursing
DOI: https://doi.org/10.2337/dc20-1137
ISSN: 0149-5992
Publisher: American Diabetes Association Inc.
Note: Funding Information: European DIAMANTE investigators for making data available. This research has been conducted using the UK Biobank resource under application number 24281. Funding. This research is supported by the Lady Davis Institute for Medical Research and the Department of Medicine, Jewish General Hospital (T.M.P.); the UK Medical Research Council; British Heart Foundation Intermediate Clinical Research Fellowship (FS/18/23/33512); and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (M.V.H.). J.B.R. is supported by the Canadian Institutes of Health Research (CIHR), the Lady Davis Institute of the Jewish General Hospital, the Canadian Foundation for Innovation, the NIH Foundation, Cancer Research UK, the Fonds de Recherche Québec Santé (FRQS), and an FRQS Clinical Research Scholarship. C.M.L. is supported by the Li Ka Shing Foundation, the NIHR Oxford Biomedical Research Centre, National Institutes of Health grants CRR00070 CR00.01 and 5P50-HD-028138-27,WT-SSI/JohnFellfunds,andWidenlife.F.W.A. is supported by University College London Hospitals NIHR Biomedical Research Centre. C.P.N. and N.J.S. are supported by the British Heart Foundation. M.I.M. is supported by Wellcome Trust grants 090532, 098381, 203141, and 212259 and National Institute of Diabetes and Digestive and Kidney Diseases grant U01-DK-105535 and was a Wellcome investigator and an NIHR senior investigator. L.M.O. is supported by a UK Medical Research Council Population Health Scientist fellowship (MR/M014509/1). S.A.E.P. is supported by a UK Medical Research Council Skills Development Fellowship (MR/P014550/1). Funding Information: This research is supported by the Lady Davis Institute for Medical Research and the Department of Medicine, Jewish General Hospital (T.M.P.); the UK Medical Research Council; British Heart Foundation Intermediate Clinical Research Fellowship (FS/18/23/33512); and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (M.V.H.). J.B.R. is supported by the Canadian Institutes of Health Research (CIHR), the Lady Davis Institute of the Jewish General Hospital, the Canadian Foundation for Innovation, the NIH Foundation, Cancer Research UK, the Fonds de Recherche Qu´ebec Sant´e (FRQS), and an FRQS Clinical Research Scholarship. C.M.L. is supported by the Li Ka Shing Foundation, the NIHR Oxford Biomedical Research Centre, National Institutes of Health grants CRR00070 CR00.01 and 5P50-HD-028138-27, WT-SSI/John Fell funds, and Widenlife. F.W.A. is supported by University College London Hospitals NIHR Biomedical Research Centre. C.P.N. and N.J.S. are supported by the British Heart Foundation. M.I.M. is supported by Wellcome Trust grants 090532, 098381, 203141, and 212259 and National Institute of Diabetes and Digestive and Kidney Diseases grant U01-DK-105535 and was a Wellcome investigator and an NIHR senior investigator. L.M.O. is supported by a UK Medical Research Council Population Health Scientist fellowship (MR/M014509/1). S.A.E.P. is supported by a UK Medical Research Council Skills Development Fellowship (MR/P014550/1). Publisher Copyright: © 2020 by the American Diabetes Association.
(Peer reviewed)