Cardiac circadian rhythms in time and space: The future is in 4D
Chirico, Nino; Van Laake, Linda W; Sluijter, Joost P G; van Mil, Alain; Dierickx, Pieterjan
(2021) Current Opinion in Pharmacology, volume 57, pp. 49 - 59
(Article)
Abstract
The circadian clock synchronizes the body into 24-h cycles, thereby anticipating variations in tissue-specific diurnal tasks, such as response to increased cardiac metabolic demand during the active period of the day. As a result, blood pressure, heart rate, cardiac output, and occurrence of fatal cardiovascular events fluctuate in a diurnal
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manner. The heart contains different cell types that make up and reside in an environment of biochemical, mechanical, and topographical signaling. Cardiac architecture is essential for proper heart development as well as for maintenance of cell homeostasis and tissue repair. In this review, we describe the possibilities of studying circadian rhythmicity in the heart by using advanced in vitro systems that mimic the native cardiac 3D microenvironment which can be tuned in time and space. Harnessing the knowledge that originates from those in vitro models could significantly improve innovative cardiac modeling and regenerative strategies.
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Keywords: Circadian rhythms, Clock manipulation, Extracellular matrix, Regeneration, Stem cells, Tissue engineering, Drug Discovery, Pharmacology, Review, Journal Article
ISSN: 1471-4892
Publisher: Elsevier BV
Note: Funding Information: The authors gratefully acknowledge support from the Marie Skłodowska-Curie Actions (Grant agreement RESCUE # 801540 ) for its financial support. This work was supported by the Netherlands Heart Foundation , Netherlands, Dekker Senior Clinical Scientist 2019, grant agreement no 2019T056 (L.V.L.), European Union H2020 program EVICARE (grant number 725229 ) (JPGS), European Union H2020 program BRAVE (grant number 874827 ) (AvM). PD was supported by the Netherlands Heart Institute, Netherlands and an American Heart Association postdoctoral fellowship, United States ( 20POST35210738 ). Funding Information: The authors gratefully acknowledge support from the Marie Sk?odowska-Curie Actions (Grant agreement RESCUE #801540) for its financial support. This work was supported by the Netherlands Heart Foundation, Netherlands, Dekker Senior Clinical Scientist 2019, grant agreement no 2019T056 (L.V.L.), European Union H2020 program EVICARE (grant number 725229) (JPGS), European Union H2020 program BRAVE (grant number 874827) (AvM). PD was supported by the Netherlands Heart Institute, Netherlands and an American Heart Association postdoctoral fellowship, United States (20POST35210738). Publisher Copyright: © 2020
(Peer reviewed)