Effects of short-term cannabidiol treatment on response to social stress in subjects at clinical high risk of developing psychosis
Appiah-Kusi, E; Petros, N; Wilson, R; Colizzi, M; Bossong, M G; Valmaggia, L; Mondelli, V; McGuire, P; Bhattacharyya, S
(2020) Psychopharmacology, volume 237, issue 4, pp. 1121 - 1130
(Article)
Abstract
Rationale: Stress is a risk factor for psychosis and treatments which mitigate its harmful effects are needed. Cannabidiol (CBD) has antipsychotic and anxiolytic effects. Objectives: We investigated whether CBD would normalise the neuroendocrine and anxiety responses to stress in clinical high risk for psychosis (CHR) patients. Methods: Thirty-two CHR patients
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and 26 healthy controls (HC) took part in the Trier Social Stress Test (TSST) and their serum cortisol, anxiety and stress associated with public speaking were estimated. Half of the CHR participants were on 600 mg/day of CBD (CHR-CBD) and half were on placebo (CHR-P) for 1 week. Results: One-way analysis of variance (ANOVA) revealed a significant effect of group (HC, CHR-P, CHR-CBD (p =.005) on cortisol reactivity as well as a significant (p =.003) linear decrease. The change in cortisol associated with experimental stress exposure was greatest in HC controls and least in CHR-P patients, with CHR-CBD patients exhibiting an intermediate response. Planned contrasts revealed that the cortisol reactivity was significantly different in HC compared with CHR-P (p =.003), and in HC compared with CHR-CBD (p =.014), but was not different between CHR-P and CHR-CBD (p =.70). Across the participant groups (CHR-P, CHR-CBD and HC), changes in anxiety and experience of public speaking stress (all p’s <.02) were greatest in the CHR-P and least in the HC, with CHR-CBD participants demonstrating an intermediate level of change. Conclusions: Our findings show that it is worthwhile to design further well powered studies which investigate whether CBD may be used to affect cortisol response in clinical high risk for psychosis patients and any effect this may have on symptoms.
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Keywords: Adolescent, Adult, Anti-Anxiety Agents/administration & dosage, Antipsychotic Agents/administration & dosage, Anxiety/blood, Cannabidiol/administration & dosage, Double-Blind Method, Female, Humans, Hydrocortisone/blood, Male, Psychotic Disorders/blood, Risk Factors, Social Behavior, Speech/drug effects, Stress, Psychological/blood, Treatment Outcome, Young Adult, Cannabidiol, Trier Social Stress Test, Psychosis, Ultra-high risk, Pharmacology, Randomized Controlled Trial, Journal Article
ISSN: 0033-3158
Publisher: Springer Verlag
Note: Funding Information: Dr. Bhattacharyya was supported by the National Institute for Health Research (NIHR) through a NIHR Clinician Scientist Award (NIHR CS-11-001) when this work was carried out and funding from the Medical Research Council (MRC) (MR/J012149/1) supported this work. Funding Information: Dr. Matthijs Bossong was supported by a Veni fellowship from the Netherlands Organisation for Scientific Research. Acknowledgements Funding Information: Dr. Appiah-Kusi was supported by the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care South London at King’s College Hospital NHS Foundation Trust when this work was carried out. Funding Information: This study represents independent research supported by the National Institute for Health Research (NIHR)/Wellcome Trust King’s Clinical Research Facility and the NIHR Biomedical Research Centre and Dementia Unit at South London and Maudsley NHS Foundation Trust and King’s College London. Publisher Copyright: © 2020, The Author(s).
(Peer reviewed)