Note: Funding Information: KSM reports research grants from AbbVie, Alcresta, Allergan, Corbus, Novoteris, Gilead, Janssen, Laurent, Novoteris, Proteostasis, Savara, Translate Bio, Vertex, and Vivus for which her institution (Nationwide Children's Hospital, Ohio State University, Columbus, OH, USA) received payment; and non-financial support from Chiesi. BWR reports research grants from Vertex, for which her institution (Seattle Children's Hospital, University of Washington School of Medicine, Seattle, WA, USA) received payment; non-financial support from Novartis; and honoraria from Vertex. SR reports research grants from AstraZeneca, Bayer, Celtaxys, Eloxx, Forest Research Institute, Galapagos (AbbVie), N30 (Nivalis), Novartis, PTC Therapeutics, Synedgen (Synspira), Vertex Pharmaceuticals, Vivus (Janssen), and Actelion (Johnson & Johnson), for which his institution (University of Alabama at Birmingham, Birmingham, AL, USA) received payment; consulting fees from Bayer, Celtaxys, Novartis, Renovion, Synedgen (Synspira), and Vertex Pharmaceuticals; fees for advisory board participation for Vertex Pharmaceuticals; and honoraria from Genentech and Boeringher Ingelheim. JW reports grants from AbbVie, Allergan, Concert, Janssen, Proteostasis, and Vertex Pharmaceuticals, for which his institution (New York Medical College, New York, NY, USA) received payment; and non-financial support from Vertex Pharmaceuticals. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.