Quantitative imaging for radiotherapy purposes
Gurney-Champion, Oliver J.; Mahmood, Faisal; van Schie, Marcel; Julian, Robert; George, Ben; Philippens, Marielle E.P.; van der Heide, Uulke A.; Thorwarth, Daniela; Redalen, Kathrine R.
(2020) Radiotherapy and Oncology, volume 146, pp. 66 - 75
(Article)
Abstract
Quantitative imaging biomarkers show great potential for use in radiotherapy. Quantitative images based on microscopic tissue properties and tissue function can be used to improve contouring of the radiotherapy targets. Furthermore, quantitative imaging biomarkers might be used to predict treatment response for several treatment regimens and hence be used as
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a tool for treatment stratification, either to determine which treatment modality is most promising or to determine patient-specific radiation dose. Finally, patient-specific radiation doses can be further tailored to a tissue/voxel specific radiation dose when quantitative imaging is used for dose painting. In this review, published standards, guidelines and recommendations on quantitative imaging assessment using CT, PET and MRI are discussed. Furthermore, critical issues regarding the use of quantitative imaging for radiation oncology purposes and resultant pending research topics are identified.
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Keywords: Biomarkers, Multimodal imaging, Multiparametric magnetic resonance imaging, Positron-emission tomography, Radiotherapy, Review, Tumor, Hematology, Oncology, Radiology Nuclear Medicine and imaging, Review, Journal Article
ISSN: 0167-8140
Publisher: Elsevier Ireland Ltd
Note: Funding Information: Funding: Oliver Gurney-Champion is funded by CRUK grant C7224/A23275 . Dr Ben George is supported by a Cancer Research UK Centres Network Accelerator Award Grant ( A21993 ) to the ART-NET consortium. Funding Information: This report represents independent research funded partially by the NIHR Biomedical Research Centre at the Royal Marsden NHS Foundation Trust and the Institute of Cancer Research. The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health. Funding Information: We thank the participants of the 2nd ESTRO Physics Workshop held in Malaga, 2018, for their involvement in the discussions that lead to this article (in arbitrary order): Julien Vautier, Ernst S. Kooreman, Martina Mori, Anders Garpebring, Anders Ahnesj?, Sofie Rahbek, Erik Almhagen, Eric Gr?nlund, Ren? Winter, Matthias Drobnitzky, Max Hellstr?m and Sara Leibfarth. We thank Kate Newbold for sharing her data with us (Fig. 2). We thank the Department of Nuclear Medicine at Odense University Hospital for providing images of PET setup (Fig. 1). Funding: Oliver Gurney-Champion is funded by CRUK grant C7224/A23275. Dr Ben George is supported by a Cancer Research UK Centres Network Accelerator Award Grant (A21993) to the ART-NET consortium. This report represents independent research funded partially by the NIHR Biomedical Research Centre at the Royal Marsden NHS Foundation Trust and the Institute of Cancer Research. The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health. Publisher Copyright: © 2020 The Authors
(Peer reviewed)
