Abstract
Arap3 is a phosphoinositide (PI) 3 kinase effector that serves as a GTPase
activating protein (GAP) for both Arf and Rho G-proteins. The protein has
multiple pleckstrin homology (PH) domains that bind preferentially phosphatidylinositol-
3,4,5–trisphosphate (PI(3,4,5,)P3) to induce translocation of Arap3
to the plasma membrane upon PI3K activation. Arap3 also contains a Ras
association (RA)
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