Note: Funding Information: MC Punt designed and performed the research, analysed and interpreted the data and wrote the manuscript. ND Ruigrok performed the research, analysed and interpreted the data and wrote the manuscript. KPM van Galen designed the research, analysed and interpreted the data and critically reviewed the manuscript. KWM Bloemenkamp, REG Schutgens and ICL Kremer Hovinga interpreted the data and critically reviewed the manuscript. All authors gave their consent to the final version of the manuscript.