Intracranial Arterial Calcification: Prevalence, Risk Factors, and Consequences: JACC Review Topic of the Week
Bartstra, Jonas W; van den Beukel, Tim C; Van Hecke, Wim; Mali, Willem P T M; Spiering, Wilko; Koek, Huiberdina L; Hendrikse, Jeroen; de Jong, Pim A; den Harder, Annemarie M
(2020) Journal of the American College of Cardiology, volume 76, issue 13, pp. 1595 - 1604
(Article)
Abstract
Intracranial large and small arterial calcifications are a common incidental finding on computed tomography imaging in the general population. Here we provide an overview of the published reports on prevalence of intracranial arterial calcifications on computed tomography imaging and histopathology in relation to risk factors and clinical outcomes. We performed
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a systematic search in Medline, with a search filter using synonyms for computed tomography scanning, (histo)pathology, different intracranial arterial beds, and calcification. We found that intracranial calcifications are a frequent finding in all arterial beds with the highest prevalence in the intracranial internal carotid artery. In general, prevalence increases with age. Longitudinal studies on calcification progression and intervention studies are warranted to investigate the possible causal role of calcification on clinical outcomes. This might open up new therapeutic directions in stroke and dementia prevention and the maintenance of the healthy brain.
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Keywords: cognitive impairment, computed tomography, dementia, epidemiology, histolog, intracranial arterial calcification, stroke, histology, Cardiology and Cardiovascular Medicine, Review, Journal Article
ISSN: 0735-1097
Publisher: Elsevier USA
Note: Funding Information: Dr. Hendrikse has received funding from the European Research Council under the European Union's Horizon 2020 Programme (H2020), grant agreement 637024 (HEARTOFSTROKE), and H2020 grant agreement 666881, SVDs@target; however, none of these was received during the conduct of the study. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Publisher Copyright: © 2020 American College of Cardiology Foundation Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
(Peer reviewed)