Note: Funding Information: GJB consults for and receives research support from Boehringer Ingelheim; all financial compensation for these services is transferred to the University Medical Center Utrecht. GJB is supported by a Vici grant 918.16.616 from the Netherlands Organisation for Scientific Research and by the EU's Horizon 2020 research and innovation programme Recognised (grant agreement no 847749 ). Funding Information: GJB consults for and receives research support from Boehringer Ingelheim; all financial compensation for these services is transferred to the University Medical Center Utrecht. GJB is supported by a Vici grant 918.16.616 from the Netherlands Organisation for Scientific Research and by the EU's Horizon 2020 research and innovation programme Recognised (grant agreement no 847749).