Klinische epidemiologie: maximale detrusorcontractiekracht gerelateerd aan leeftijd en geslacht

Abstract

To report clinical epidemiology of detrusor (bladder) muscle contraction maximum related to ageing in patients referred with signs and symptoms of lower urinary tract dysfunction. One thousand three hundred and eight urodynamic pressure-flow measurements were analyzed in retrospective. Standard measures of detrusor muscle voiding contraction strength were compared for gender and ranked by age (range 20–90 years). A decline in maximum detrusor contraction strength was observed when the results were ranked according to age. Detrusor muscle maximum voiding contraction was on average 30% less powerful in older women and 12% less powerful in the aged men, when compared to the younger. This is transversal data – interpreted in a longitudinal manner – and from persons referred to specialist care with (the full spectrum of) signs and symptoms of lower urinary tract dysfunction. Clinical epidemiologic evaluation of patients referred with lower urinary tract symptoms, found lower detrusor maximum contraction strength in higher-age cohorts, both for women as for men. The maximum detrusor strength difference in association with age was larger in women than in men. These findings cannot simply be generalized to an asymptomatic population.