CXCL4 suppresses tolerogenic immune signature of monocyte-derived dendritic cells

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CXCL4 suppresses tolerogenic immune signature of monocyte-derived dendritic cells
 
Silva-Cardoso, Sandra C; Tao, Weiyang; Fernández, Beatriz Malvar; Boes, Marianne; Radstake, Timothy R D J; Pandit, Aridaman
(2020) European Journal of Immunology, volume 50, issue 10, pp. 1598 - 1601
(Comment)
Abstract
RNA sequencing and DNA methylomic profiling were performed after differentiating monocytes for 6 days into moDCs with/without CXCL4 presence. We show that CXCL4 downregulates genes associated with tolerogenicity in DCs including C1Q. Expression profiles of C1Q genes were negatively correlated with their DNA methylation profiles and with immunogenic genes.
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Keywords: C1q, CXCL4, DNA methylation, Monocyte-derived dendritic cells, RNA sequencing, Immunology and Allergy, Immunology, Journal Article
DOI: https://doi.org/10.1002/eji.201948341
ISSN: 0014-2980
Publisher: Wiley-VCH Verlag
Note: Funding Information: This work was supported by a Ph.D. grant from the Portuguese Fundação para a Ciência e a Tecnologia (SFRH/BD/89643/2012) (to S.C.S.C.); China Scholarship Council (CSC) No. 201606300050 (to W.T.); Netherlands Organisation for Scientific Research (NWO) grant number: 016.Veni.178.027 (to A.P.); ERC Starting grant, a grant from the Dutch Arthritis Foundation and Pre‐Seed grant Dutch Association of Science (NWO) (to T.R.D.J.R.). Funding Information: This work was supported by a Ph.D. grant from the Portuguese Funda??o para a Ci?ncia e a Tecnologia (SFRH/BD/89643/2012) (to S.C.S.C.); China Scholarship Council (CSC) No. 201606300050 (to W.T.); Netherlands Organisation for Scientific Research (NWO) grant number: 016.Veni.178.027 (to A.P.); ERC Starting grant, a grant from the Dutch Arthritis Foundation and Pre-Seed grant Dutch Association of Science (NWO) (to T.R.D.J.R.).
(Peer reviewed)