Role of Biomaterials and Controlled Architecture on Tendon/Ligament Repair and Regeneration
No, Young Jung; Castilho, Miguel; Ramaswamy, Yogambha; Zreiqat, Hala
(2020) Advanced materials, volume 32, issue 18
(Article)
Abstract
Engineering synthetic scaffolds to repair and regenerate ruptured native tendon and ligament (T/L) tissues is a significant engineering challenge due to the need to satisfy both the unique biological and biomechanical properties of these tissues. Long-term clinical outcomes of synthetic scaffolds relying solely on high uniaxial tensile strength are poor
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with high rates of implant rupture and synovitis. Ideal biomaterials for T/L repair and regeneration need to possess the appropriate biological and biomechanical properties necessary for the successful repair and regeneration of ruptured tendon and ligament tissues.
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Keywords: fiber architecture, fiber-reinforced hydrogel, hydrogel, ligaments, synthetic biomaterials, tendons, Mechanics of Materials, Mechanical Engineering, General Materials Science, Review, Journal Article
ISSN: 0935-9648
Publisher: Wiley-Blackwell
Note: Funding Information: The authors gratefully acknowledge the following agencies for their financial support: Australian Research Council Training Centre for Innovative Bioengineering, the Australian National Health and Medical Research Council, Radcliffe Institute for Advanced Study at Harvard University, the Rebecca L. Cooper Medical Research Foundation, the strategic alliance University Medical Center Utrecht—Technical University Eindhoven and the partners of Regenerative Medicine Crossing Borders ( https://www.regmedxb.com ) and powered by Health‐Holland, Top Sector Life Sciences & Health. Funding Information: The authors gratefully acknowledge the following agencies for their financial support: Australian Research Council Training Centre for Innovative Bioengineering, the Australian National Health and Medical Research Council, Radcliffe Institute for Advanced Study at Harvard University, the Rebecca L. Cooper Medical Research Foundation, the strategic alliance University Medical Center Utrecht—Technical University Eindhoven and the partners of Regenerative Medicine Crossing Borders (https://www.regmedxb.com) and powered by Health-Holland, Top Sector Life Sciences & Health. Publisher Copyright: © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
(Peer reviewed)