Thromboembolic events and apparent heparin resistance in patients infected with SARS-CoV-2
Beun, Robert; Kusadasi, Nuray; Sikma, Maaike; Westerink, Jan; Huisman, Albert
(2020) International Journal of Laboratory Hematology, volume 42, issue S1, pp. 19 - 20
(Comment)
Abstract
In March 2020, the global healthcare system is overwhelmed by patients infected with SARS-CoV-2, which is the cause of the coronavirus pandemic (Covid-2019). A large number of these patients end up in the intensive care units (ICU) with critical illness requiring mechanical ventilation. One of the most important clinical features
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of the infection is a profound coagulopathy. In a recent cohort study 71% of patients who eventually died matched the ISTH criteria for disseminated intravascular coagulation (DIC), while this percentage was only 0.6% in patients who survived.
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Keywords: COVID19, SARS-CoV-2, corona, SARS, heparin, Intensive Care Units, Pandemics, Humans, Middle Aged, Pulmonary Embolism/complications, Drug Tolerance, Male, Anticoagulants/therapeutic use, Factor Xa/analysis, Betacoronavirus/isolation & purification, Drug Monitoring/methods, Factor VIII/analysis, Clinical Laboratory Techniques/methods, Fibrinogen/analysis, Pneumonia, Viral/complications, Biomarkers/blood, Female, Heparin/therapeutic use, Aged, Coronavirus Infections/complications, Fibrin Fibrinogen Degradation Products/analysis, Cohort Studies, Disseminated Intravascular Coagulation/complications, Biochemistry, medical, Hematology, Clinical Biochemistry, Letter
ISSN: 1751-5521
Publisher: Wiley-Blackwell
Note: This article is protected by copyright. All rights reserved.
(Peer reviewed)
