Extensions of Multiple-Group Item Response Theory Alignment: Application to Psychiatric Phenotypes in an International Genomics Consortium
Mansolf, Maxwell; Vreeker, Annabel; Reise, Steven P; Freimer, Nelson B; Glahn, David C; Gur, Raquel E; Moore, Tyler M; Pato, Carlos N; Pato, Michele T; Palotie, Aarno; Holm, Minna; Suvisaari, Jaana; Partonen, Timo; Kieseppä, Tuula; Paunio, Tiina; Boks, Marco; Kahn, René; Ophoff, Roel A; Bearden, Carrie E; Loohuis, Loes Olde; Teshiba, Terri; deGeorge, Daniella; Bilder, Robert M; GROUP Investigators
(2020) Educational and Psychological Measurement, volume 80, issue 5, pp. 870 - 909
(Article)
Abstract
Large-scale studies spanning diverse project sites, populations, languages, and measurements are increasingly important to relate psychological to biological variables. National and international consortia already are collecting and executing mega-analyses on aggregated data from individuals, with different measures on each person. In this research, we show that Asparouhov and Muthén's alignment
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method can be adapted to align data from disparate item sets and response formats. We argue that with these adaptations, the alignment method is well suited for combining data across multiple sites even when they use different measurement instruments. The approach is illustrated using data from the Whole Genome Sequencing in Psychiatric Disorders consortium and a real-data-based simulation is used to verify accurate parameter recovery. Factor alignment appears to increase precision of measurement and validity of scores with respect to external criteria. The resulting parameter estimates may further inform development of more effective and efficient methods to assess the same constructs in prospectively designed studies.
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Keywords: data integration, differential item functioning, harmonization, mega-analysis, test equating, Education, Developmental and Educational Psychology, Applied Psychology, Applied Mathematics, Journal Article
ISSN: 0013-1644
Publisher: SAGE Publications Inc.
Note: Funding Information: We are grateful for the generosity of time and effort by the patients, their families and healthy subjects. Furthermore we would like to thank all research personnel involved in the GROUP project, in particular: Joyce van Baaren, Erwin Veermans, Ger Driessen, Truda Driesen, Erna van ?t Hag. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by grants from the NIMH, specifically U01 MH105653 (M.B.), U01 MH105641 (S.A.M.), U01 MH105573 (C.N.P.), U01 MH105670 (D.B.G.), U01 MH105575 (M.W.S., A.J.W.), U01 MH105669 (M.J.D., K.E.), U01 MH105575 (N.B.F., D.H.G., R.A.O.), U01 MH105666 (A.P.), U01 MH105630 (D.C.G.), U01 MH105632 (J.B.), U01 MH105634 (R.E.G.), U01 MH100239-03S1 (M.W.S., S.J.S., A.J.W.), R01 MH095454 (N.B.F.), R01 MH114152 (R.A.O., R.M.B.), R01 MH118514 (R.M.B.), and R01 MH101478 (R.M.B.); by grants from the Simons Foundation (SFARI No. 385110, M.W.S., S.J.S., A.J.W., D.B.G., SFARI No. 401457 [D.H.G.]); and by a gift from the Stanley Foundation (S.E.H.). The infrastructure for the GROUP study is funded through the Geestkracht programme of the Dutch Health Research Council (Zon-Mw, grant number 10-000-1001), and matching funds from participating pharmaceutical companies (Lundbeck, AstraZeneca, Eli Lilly, Janssen Cilag) and universities and mental health care organizations (Amsterdam: Academic Psychiatric Centre of the Academic Medical Center and the mental health institutions: GGZ Ingeest, Arkin, Dijk en Duin, GGZ Rivierduinen, Erasmus Medical Centre, GGZ Noord Holland Noord. Groningen: University Medical Center Groningen and the mental health institutions: Lentis, GGZ Friesland, GGZ Drenthe, Dimence, Mediant, GGNet Warnsveld, Yulius Dordrecht and Parnassia psycho-medical center The Hague. Maastricht: Maastricht University Medical Centre and the mental health institutions: GGzE, GGZ Breburg, GGZ Oost-Brabant, Vincent van Gogh voor Geestelijke Gezondheid, Mondriaan, Virenze riagg, Zuyderland GGZ, MET ggz, Universitair Centrum Sint-Jozef Kortenberg, CAPRI University of Antwerp, PC Ziekeren Sint-Truiden, PZ Sancta Maria Sint-Truiden, GGZ Overpelt, OPZ Rekem. Utrecht: University Medical Center Utrecht and the mental health institutions Altrecht, GGZ Centraal and Delta). Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by grants from the NIMH, specifically U01 MH105653 (M.B.), U01 MH105641 (S.A.M.), U01 MH105573 (C.N.P.), U01 MH105670 (D.B.G.), U01 MH105575 (M.W.S., A.J.W.), U01 MH105669 (M.J.D., K.E.), U01 MH105575 (N.B.F., D.H.G., R.A.O.), U01 MH105666 (A.P.), U01 MH105630 (D.C.G.), U01 MH105632 (J.B.), U01 MH105634 (R.E.G.), U01 MH100239-03S1 (M.W.S., S.J.S., A.J.W.), R01 MH095454 (N.B.F.), R01 MH114152 (R.A.O., R.M.B.), R01 MH118514 (R.M.B.), and R01 MH101478 (R.M.B.); by grants from the Simons Foundation (SFARI No. 385110, M.W.S., S.J.S., A.J.W., D.B.G., SFARI No. 401457 [D.H.G.]); and by a gift from the Stanley Foundation (S.E.H.). The infrastructure for the GROUP study is funded through the Geestkracht programme of the Dutch Health Research Council (Zon-Mw, grant number 10-000-1001), and matching funds from participating pharmaceutical companies (Lundbeck, AstraZeneca, Eli Lilly, Janssen Cilag) and universities and mental health care organizations (Amsterdam: Academic Psychiatric Centre of the Academic Medical Center and the mental health institutions: GGZ Ingeest, Arkin, Dijk en Duin, GGZ Rivierduinen, Erasmus Medical Centre, GGZ Noord Holland Noord. Groningen: University Medical Center Groningen and the mental health institutions: Lentis, GGZ Friesland, GGZ Drenthe, Dimence, Mediant, GGNet Warnsveld, Yulius Dordrecht and Parnassia psycho-medical center The Hague. Maastricht: Maastricht University Medical Centre and the mental health institutions: GGzE, GGZ Breburg, GGZ Oost-Brabant, Vincent van Gogh voor Geestelijke Gezondheid, Mondriaan, Virenze riagg, Zuyderland GGZ, MET ggz, Universitair Centrum Sint-Jozef Kortenberg, CAPRI University of Antwerp, PC Ziekeren Sint-Truiden, PZ Sancta Maria Sint-Truiden, GGZ Overpelt, OPZ Rekem. Utrecht: University Medical Center Utrecht and the mental health institutions Altrecht, GGZ Centraal and Delta). Publisher Copyright: © The Author(s) 2020.
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