Associations between illness cognitions and health-related quality of life in the first year after diagnosis of amyotrophic lateral sclerosis
Kruitwagen-van Reenen, E T H; Mwm, Post; van Groenestijn, A; van den Berg, L H; Jma, Visser-Meily
(2020) Journal of Psychosomatic Research, volume 132, pp. 1 - 6
(Article)
Abstract
OBJECTIVE: To describe illness cognitions among patients with amyotrophic lateral sclerosis (ALS), to study cross-sectional associations between illness cognitions and health-related quality of life (HRQoL) and to study the predictive value of illness cognitions measured shortly after the diagnosis for HRQoL at follow-up. METHODS: Prospective longitudinal design. We administered Self-report
... read more
questionnaires at study onset (n = 72) and follow-up (n = 48). Median follow-up period was 10.0 months. At baseline median ALS Functional Rating Scale-Revised was 43, median time since onset of symptoms was 13.6 months, 79% of patients presented with spinal onset. Illness cognitions Helplessness, Acceptance and Disease Benefits were measured with the Illness Cognitions Questionnaire (ICQ) and HRQoL with the ALS Assessment Questionnaire (ALSAQ-40). Correlational and regression analyses were used. RESULTS: Patients experienced more Helplessness at follow-up. We found no significant changes in Acceptance or Disease Benefits at follow-up. In cross-sectional analyses, Helplessness was independently related to worse HRQoL at baseline (β = 0.44; p = .001) and Acceptance and Disease Benefits were independently related to worse HRQoL at follow-up (β = -0.17, p = .045) and (β = -0.186, p = .03 respectively). Longitudinal analyses showed that, adjusted for disease severity at baseline, Helplessness at baseline was a predictor of worse HRQoL at follow-up (β = 0.43; p = .006). None of the illness cognitions were a significant predictor of HRQoL with adjustment for baseline HRQoL. CONCLUSION: Helplessness was independently associated with HRQoL in the cross-sectional and longitudinal analyses. These results can help us identify patients shortly after diagnosis who might benefit from psychological interventions.
show less
Download/Full Text
Keywords: Amyotrophic lateral sclerosis, Health related quality of life, Illness cognitions, Longitudinal, Psychological factors, Prospective Studies, Humans, Middle Aged, Male, Quality of Life/psychology, Young Adult, Amyotrophic Lateral Sclerosis/psychology, Adolescent, Aged, 80 and over, Adult, Female, Aged, Cognition/physiology, Longitudinal Studies, Psychiatry and Mental health, Clinical Psychology, Journal Article, Research Support, Non-U.S. Gov't, Multicenter Study
ISSN: 0022-3999
Publisher: Elsevier Inc.
Note: Funding Information: L.H. van den Berg serves on scientific advisory boards for ARISLA the Thierry Latran Foundation, Biogen, Cytokinetics and Orion; serves on the editorial board of Amyotrophic Lateral Sclerosis, The Journal of Neurology, Neurosurgery and Psychiatry; and receives research support from the Prinses Beatrix Fonds, Netherlands ALS Foundation, and the Netherlands Organization for Scientific Research VICI Grant.Prinses Beatrix Spierfonds and the Netherlands Organization for Health Research and Development. Funding Information: L.H. van den Berg serves on scientific advisory boards for ARISLA the Thierry Latran Foundation, Biogen, Cytokinetics and Orion; serves on the editorial board of Amyotrophic Lateral Sclerosis, The Journal of Neurology, Neurosurgery and Psychiatry; and receives research support from the Prinses Beatrix Fonds , Netherlands ALS Foundation , and the Netherlands Organization for Scientific Research VICI Grant . Publisher Copyright: © 2020 Elsevier Inc.
(Peer reviewed)