Impact of delivery mode-associated gut microbiota dynamics on health in the first year of life

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Impact of delivery mode-associated gut microbiota dynamics on health in the first year of life
 
Reyman, Marta; van Houten, Marlies A.; van Baarle, Debbie; Bosch, Astrid A.T.M.; Man, Wing Ho; Chu, Mei Ling J.N.; Arp, Kayleigh; Watson, Rebecca L.; Sanders, Elisabeth A.M.; Fuentes, Susana; Bogaert, Debby
(2019) Nature Communications, volume 10, issue 1
(Article)
Abstract
The early-life microbiome appears to be affected by mode of delivery, but this effect may depend on intrapartum antibiotic exposure. Here, we assess the effect of delivery mode on gut microbiota, independent of intrapartum antibiotics, by postponing routine antibiotic administration to mothers until after cord clamping in 74 vaginally delivered and 46 ... read more
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Keywords: General Chemistry, General Biochemistry,Genetics and Molecular Biology, General Physics and Astronomy
DOI: https://doi.org/10.1038/s41467-019-13014-7
ISSN: 2041-1723
Publisher: Nature Publishing Group
Note: Funding Information: The authors are most grateful for the participation of all the children and their families. We would like to acknowledge all the members of the research team of the Spaarne Gasthuis Academy, the Department of Obstetrics and Gynecology of the Spaarne Gas-thuis (Hoofddorp and Haarlem, the Netherlands) and participating midwifery clinics. We would also like to acknowledge Edinburgh Genomics for executing the WGS sequencing and Katherine Emelianova for the bioinformatic analysis of the shotgun sequences. This work was supported in part by the Netherlands Organisation for Scientific Research (NWO-VIDI; grant 91715359) and CSO/NRS Scottish Senior Clinical Fellowship award (SCAF/16/03). The study was co-sponsored by the Spaarne Hospital Hoofdorp and Haarlem and the University Medical Centre Utrecht, The Netherlands. Funding Information: E.A.M.S. declares to have received unrestricted research support from Pfizer, grant support for vaccine studies from Pfizer and GSK, and fees paid to the institution for advisory boards or participation in independent data-monitoring committees for Pfizer and GSK. D.B. declares to have received unrestricted fees paid to the institution for advisory work for Friesland Campina and well as research support from Nutricia. None of the fees or grants listed here were received for the research described in this paper. No other authors reported financial disclosures. None of the other authors report competing interests. Publisher Copyright: © 2019, The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
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